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Evaluation of biodegradable polyester-co-lactone microparticles for protein delivery.

Tawfeek, HM and Khidr, SH and Samy, EM and Ahmed, SM and Gaskell, EE and Hutcheon, GA (2014) Evaluation of biodegradable polyester-co-lactone microparticles for protein delivery. Drug Development and Industrial Pharmacy, 40 (9). pp. 1213-1222. (Submitted)

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Abstract

Abstract Poly(glycerol adipate-co-ω-pentadecalactone) (PGA-co-PDL) was previously evaluated for the colloidal delivery of α-chymotrypsin. In this article, the effect of varying polymer molecular weight (MW) and chemistry on particle size and morphology; encapsulation efficiency; in vitro release; and the biological activity of α-chymotrypsin (α-CH) and lysozyme (LS) were investigated. Microparticles were prepared using emulsion solvent evaporation and evaluated by various methods. Altering the MW or monomer ratio of PGA-co-PDL did not significantly affect the encapsulation efficiency and overall poly(1,3-propanediol adipate-co-ω-pentadecalactone) (PPA-co-PDL) demonstrated the highest encapsulation efficiency. In vitro release varied between polymers, and the burst release for α-CH-loaded microparticles was lower when a higher MW PGA-co-PDL or more hydrophobic PPA-co-PDL was used. The results suggest that, although these co-polyesters could be useful for protein delivery, little difference was observed between the different PGA-co-PDL polymers and PPA-co-PDL generally provided a higher encapsulation and slower release of enzyme than the other polymers tested.

Item Type: Article
Subjects: R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Divisions: Pharmacy & Biomolecular Sciences
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Date Deposited: 10 Sep 2014 13:18
Last Modified: 01 Oct 2015 23:50
URI: http://researchonline.ljmu.ac.uk/id/eprint/125

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