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Genomic imprinting and mammalian reproduction

Swaney, WT (2011) Genomic imprinting and mammalian reproduction. HORMONES AND BEHAVIOR, 59 (3). pp. 369-374. ISSN 0018-506X

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Abstract

Among animals, genomic imprinting is a uniquely mammalian phenomenon in which certain genes are monoallelically expressed according to their parent of origin. This silencing of certain alleles often involves differential methylation at regulatory regions associated with imprinted genes and must be recapitulated at every generation with the erasure and reapplication of these epigenetic marks in the germline. Imprinted genes encode regulatory proteins that play key roles in fetal growth and development, but they also exert wider effects on mammalian reproduction. Genetic knockout experiments have shown that certain paternally expressed imprinted genes regulate post-natal behavior in offspring as well as reproductive behaviors in males and females. These deficits involve changes in hypothalamic function affecting multiple areas and different neurochemical pathways. Paternally expressed genes are highly expressed in the hypothalamus which regulates growth, metabolism and reproduction and so are well placed to influence all aspects of reproduction from adults to the resultant offspring. Coadaptation between offspring and mother appears to have played an important role in the evolution of some paternally expressed genes, but the influence of these genes on male reproductive behavior also suggests that they have evolved to regulate their own transmission to successive generations via the male germline.©

Item Type: Article
Uncontrolled Keywords: 11 Medical And Health Sciences, 06 Biological Sciences
Subjects: Q Science > QL Zoology
Divisions: Natural Sciences and Psychology
Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE
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Date Deposited: 05 Jun 2015 12:12
Last Modified: 07 Sep 2017 06:06
DOI or Identification number: 10.1016/j.yhbeh.2010.05.012
URI: http://researchonline.ljmu.ac.uk/id/eprint/1366

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