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Myoblast models of skeletal muscle hypertrophy and atrophy

Sharples, AP and Stewart, CE (2011) Myoblast models of skeletal muscle hypertrophy and atrophy. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE, 14 (3). pp. 230-236. ISSN 1363-1950

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Abstract

Purpose of review: To highlight recent breakthroughs and controversies in the use of myoblast models to uncover cellular and molecular mechanisms regulating skeletal muscle hypertrophy and atrophy.

Recent findings: Myoblast cultures provide key mechanistic models of the signalling and molecular pathways potentially employed by skeletal muscle in-vivo to regulate hypertrophy and atrophy. Recently the controversy as to whether insulin-like growth factor (IGF)-I is important in hypertrophy following mechanical stimuli vs. alternative pathways has been hotly debated and is discussed. The role of myostatin in myoblast models of atrophy and interactions between protein synthetic pathways including Akt/mTOR and the ‘atrogenes’ are explored.

Summary: Targeted in-vivo experimentation directed by skeletal muscle cell culture and bioengineering (three-dimensional skeletal muscle cell culture models) will provide key biomimetic and mechanistic data regarding hypertrophy and atrophy and thus enable the development of important strategies for tackling muscle wasting associated with ageing and disease processes.

Item Type: Article
Uncontrolled Keywords: 11 Medical And Health Sciences
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: LIPPINCOTT WILLIAMS & WILKINS
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Date Deposited: 18 Jun 2015 12:51
Last Modified: 18 Jun 2015 12:51
DOI or Identification number: 10.1097/MCO.0b013e3283457ade
URI: http://researchonline.ljmu.ac.uk/id/eprint/1401

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