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Could GLUT12 be a Potential Therapeutic Target in Cancer Treatment? A Preliminary Report

Pujol-Gimenez, J and de Heredia, FP and Angel Idoate, M and Airley, R and Pilar Lostao, M and Evans, AR (2015) Could GLUT12 be a Potential Therapeutic Target in Cancer Treatment? A Preliminary Report. JOURNAL OF CANCER, 6 (2). pp. 139-143. ISSN 1837-9664

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Abstract

Background: Recent studies proposed GLUT12 to be a major glucose transporter involved in the glycolytic metabolism of cancer cells.

Methods: GLUT12 expression was determined by immunohistochemistry in a selection of cancer cell lines and a tumour spheroid model.

Results: GLUT12 expression was high in A549 and RH-36; low in HT29; and absent in NB-EB cancer cell lines. GLUT12 expression was located in the necrotic centre of HT29 spheroids, which is characterised by anaerobic metabolism.

Conclusion: The data supports the involvement of GLUT12 in the glycolytic metabolism of cancer cells and therefore, its potential as a novel therapeutic target for cancer treatment.

Item Type: Article
Uncontrolled Keywords: Science & Technology; Life Sciences & Biomedicine; Oncology; GLUT12; Cancer cell lines; Spheroid; Immunohistochemistry; Glycolytic metabolism; FACILITATIVE GLUCOSE TRANSPORTERS; HUMAN PLACENTA; TUMOR HYPOXIA; EXPRESSION; P53; LOCALIZATION; TISSUES; AGENTS; CELLS
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Pharmacy & Biomolecular Sciences
Publisher: IVYSPRING INT PUBL
Related URLs:
Date Deposited: 13 Nov 2015 13:52
Last Modified: 13 Nov 2015 13:52
DOI or Identification number: 10.7150/jca.10429
URI: http://researchonline.ljmu.ac.uk/id/eprint/1741

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