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Recent Advances Using Supercritical Fluid Techniques for Pulmonary Administration of Macromolecules via Dry Powder Formulations

Alfagih, IM and Alanazi, FK and Hutcheon, GA and Saleem, IY (2011) Recent Advances Using Supercritical Fluid Techniques for Pulmonary Administration of Macromolecules via Dry Powder Formulations. Drug Delivery Letters, 1 (2). pp. 128-134. ISSN 2210-304X

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Abstract

Growing demands on a suitable formulation method that ensures the stability of the active compound coupled with the limitations of current methods (milling, lyophilization, spray drying, and freeze spray drying) has brought wide attention to supercritical fluid (SCF) technology. Advantages of using the SCF technology comprise its high abilities, adaptability in providing alternative processing methods, high compressibility and diffusivity of the supercritical fluid, capability as an alternative for conventional organic solvents, and the option to attain different processing parameters which would be otherwise difficult to conduct with traditional methods. This review proposes to present an up-to-date outlook on dry powder pulmonary formulations of macromolecules using SCF technology.

Item Type: Article
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Bentham Science
Date Deposited: 06 Oct 2015 09:37
Last Modified: 06 Oct 2015 09:44
URI: http://researchonline.ljmu.ac.uk/id/eprint/1751

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