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Utility of the hypertriglyceridemic waist phenotype in the cardiometabolic risk assessment of youth stratified by body mass index

Buchan, DS and Boddy, LM and Despres, JP and Grace, FM and Sculthorpe, N and Mahoney, C and Baker, JS (2015) Utility of the hypertriglyceridemic waist phenotype in the cardiometabolic risk assessment of youth stratified by body mass index. Pediatric Obesity. ISSN 2047-6310

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Abstract

Background: It is unclear whether the Hypertriglyceridemic Waist Phenotype can be used to identify those at most risk of cardiometabolic disorders.

Objectives: The utility of the Hypertriglyceridemic Waist Phenotype (HTWP) as a useful predictor of cardiometabolic risk in youth stratified by body mass index (BMI) was assessed.

Methods: Three hundred and eighty seven children (12-17.5 years) were used within this cross-sectional study. Participants were classified as normal weight or overweight/obese according to the IOTF criteria. The HTWP phenotype was defined as having a waist circumference ≥ 90th percentile for age and gender with concomitant triglyceride concentrations ≥ 1.24 mmol/L. Cardiometabolic risk profiles were compared using MANCOVA.

Results: Normal weight participants with the HTWP had significantly higher levels of C-reactive protein 2.6 ± 0.4 vs. 1.6 ± 0.3 mg/L (P < 0.05) and cardiometabolic risk scores (1.3 ± 0.3 vs. -0.7 ± 0.2 and 2.1 ± 0.4 vs. -0.5 ± 0.2; both P < 0.05) compared to those of a normal weight without the HTWP. Overweight/obese participants with the HTWP had significantly higher C-reactive protein levels (3.5 ± 0.6 vs. 2.6 ± 0.5; P < 0.05) as well as both cardiometabolic risk scores (1.6 ± 0.6 vs. 0.9 ± 0.2 and 2.2 ± 0.6 vs. 0.8 ± 0.2; both P < 0.001) when compared to overweight/obese participants without the HTWP.

Conclusions:
The HTWP may serve as a simple and clinically useful approach to identify youth at increased cardiometabolic risk.

Item Type: Article
Additional Information: This is the peer reviewed version of the following article: Buchan, D. S., Boddy, L. M., Despres, J.-P., Grace, F. M., Sculthorpe, N., Mahoney, C. and Baker, J. S. (2015), Utility of the hypertriglyceridemic waist phenotype in the cardiometabolic risk assessment of youth stratified by body mass index. Pediatric Obesity which has been published in final form at http://dx.doi.org/10.1111/ijpo.12061 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Wiley: 12 months
Date Deposited: 18 Aug 2015 15:15
Last Modified: 07 Aug 2016 23:50
DOI or Identification number: 10.1111/ijpo.12061
URI: http://researchonline.ljmu.ac.uk/id/eprint/1866

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