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Effects of Functional Electrical Stimulation on Denervated Laryngeal Muscle in a Large Animal Model

Cheetham, J and Cercone, M and Mitchell, LM and Ducharme, NG and Hermanson, JW and Perkins, JD and Piercy, RJ and Jarvis, JC and Maw, M (2015) Effects of Functional Electrical Stimulation on Denervated Laryngeal Muscle in a Large Animal Model. Artificial Organs, 39 (10). pp. 876-885. ISSN 0160-564X

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Abstract

Bilateral vocal fold paralysis (BVCP) is a life-threatening condition that follows injury to the Recurrent Laryngeal nerve (RLn) and denervation of the intrinsic laryngeal musculature. Functional electrical stimulation (FES) enables restoration and control of a wide variety of motor functions impaired by lower motor neuron lesions. Here we evaluate the effects of FES on the sole arytenoid abductor, the posterior cricoarytenoid (PCA) muscle in a large animal model of RLn injury. Ten horses were instrumented with two quadripolar intramuscular electrodes in the left PCA muscle. Following a 12-week denervation period, the PCA was stimulated using a once-daily training session for 8 weeks in seven animals. Three animals were used as unstimulated controls. Denervation produced a significant increase in rheobase (P<0.001). Electrical stimulation produced a 30% increase in fiber diameter in comparison with the unstimulated control group (33.9±2.6μm FES+, 23.6±4.2μm FES-, P=0.04). A trend toward a decrease in the proportion of type 1 (slow) fibers and an increase in type 2a (fast) fibers was also observed. Despite these changes, improvement in PCA function at rest was not observed. These data suggest that electrical stimulation using a relatively conservative set of stimulation parameters can reverse the muscle fiber atrophy produced by complete denervation while avoiding a shift to a slow (type 1) fiber type.

Item Type: Article
Uncontrolled Keywords: 0903 Biomedical Engineering, 1103 Clinical Sciences
Subjects: Q Science > QL Zoology
R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Wiley
Date Deposited: 25 Nov 2016 11:25
Last Modified: 09 Sep 2017 06:17
DOI or Identification number: 10.1111/aor.12624
URI: http://researchonline.ljmu.ac.uk/id/eprint/2262

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