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Use of QSARs in international decision-making frameworks to predict health effects of chemical substances

Cronin, MTD and Jaworska, JS and Walker, JD and Comber, MHI and Watts, CD and Worth, AP (2003) Use of QSARs in international decision-making frameworks to predict health effects of chemical substances. ENVIRONMENTAL HEALTH PERSPECTIVES, 111 (10). pp. 1391-1401. ISSN 0091-6765

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Abstract

This article is a review of the use of quantitative (and qualitative) structure-activity relationships (QSARs and SARs) by regulatory agencies and authorities to predict acute toxicity, mutagenicity, carcinogenicity, and other health effects. A number of SAR and QSAR applications, by regulatory agencies and authorities, are reviewed. These include the use of simple QSAR analyses, as well as the use of multivariate QSARs, and a number of different expert system approaches.

Item Type: Article
Additional Information: Reproduced with permission from Environmental Health Perspectives
Uncontrolled Keywords: 11 Medical And Health Sciences, 05 Environmental Sciences
Subjects: R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Divisions: Pharmacy & Biomolecular Sciences
Publisher: US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
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Date Deposited: 02 Feb 2016 15:21
Last Modified: 02 Feb 2016 15:21
DOI or Identification number: 10.1289/ehp.5760
URI: http://researchonline.ljmu.ac.uk/id/eprint/2304

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