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A Novel Microwave Sensor to Detect Specific Biomarkers in Human Cerebrospinal Fluid and Their Relationship to Cellular Ischemia During Thoracoabdominal Aortic Aneurysm Repair

Fok, M and Bashir, M and Fraser, H and Strouther, N and Mason, A (2015) A Novel Microwave Sensor to Detect Specific Biomarkers in Human Cerebrospinal Fluid and Their Relationship to Cellular Ischemia During Thoracoabdominal Aortic Aneurysm Repair. JOURNAL OF MEDICAL SYSTEMS, 39 (4). pp. 1-5. ISSN 0148-5598

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Abstract

Thoraco-abdominal aneurysms (TAAA) represents a particularly lethal vascular disease that without surgical repair carries a dismal prognosis. However, there is an inherent risk from
surgical repair of spinal cord ischaemia that can result in paraplegia. One method of reducing
this risk is cerebrospinal fluid (CSF) drainage. We believe that the CSF contains clinically
significant biomarkers that can indicate impending spinal cord ischaemia. This work
therefore presents a novel measurement method for proteins, namely albumin, as a precursor
to further work in this area. The work uses an interdigitated electrode (IDE) sensor and
shows that it is capable of detecting various concentrations of albumin (from 0 to 100 g/L)
with a high degree of repeatability at 200 MHz (R2 = 0.991) and 4 GHz (R2 = 0.975).

Item Type: Article
Additional Information: The final publication is available at Springer via http://dx.doi.org/10.1007/s10916-015-0208-4
Uncontrolled Keywords: 0806 Information Systems, 1117 Public Health And Health Services
Subjects: R Medicine > R Medicine (General)
R Medicine > RD Surgery
Divisions: Built Environment
Publisher: SPRINGER
Related URLs:
Date Deposited: 23 Nov 2015 13:13
Last Modified: 17 Feb 2016 00:50
DOI or Identification number: 10.1007/s10916-015-0208-4
URI: http://researchonline.ljmu.ac.uk/id/eprint/2372

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