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Impact of eight weeks of repeated ischaemic preconditioning on brachial artery and cutaneous microcirculatory function in healthy males

Jones, H and Nyakayiru, J and Bailey, TG and Green, DJ and Cable, NT and Sprung, VS and Hopkins, ND and Thijssen, DHJ (2015) Impact of eight weeks of repeated ischaemic preconditioning on brachial artery and cutaneous microcirculatory function in healthy males. EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY, 22 (8). ISSN 2047-4873

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Abstract

Background Ischaemic preconditioning has well-established cardiac and vascular protective effects. Short interventions (one week) of daily ischaemic preconditioning episodes improve conduit and microcirculatory function. This study examined whether a longer (eight weeks) and less frequent (three per week) protocol of repeated ischaemic preconditioning improves vascular function.
Methods Eighteen males were randomly allocated to either ischaemic preconditioning (22.4 ± 2.3 years, 23.7 ± 3.1 kg/m2) or a control intervention (26.0 ± 4.8 years, 26.4 ± 1.9 kg/m2). Brachial artery endothelial-dependent (FMD), forearm cutaneous microvascular function and cardiorespiratory fitness were assessed at zero, two and eight weeks.
Results A greater improvement in FMD was evident following ischaemic preconditioning training compared with control at weeks 2 (2.24% (0.40, 4.08); p=0.02) and 8 (1.11% (0.13, 2.10); p=0.03). Repeated ischaemic preconditioning did not change cutaneous microcirculatory function or fitness.
Conclusions These data indicate that a feasible and practical protocol of regular ischaemic preconditioning episodes improves endothelial function in healthy individuals within two weeks, and these effects persist following repeated ischaemic preconditioning for eight weeks.

Item Type: Article
Uncontrolled Keywords: Science & Technology; Life Sciences & Biomedicine; Cardiac & Cardiovascular Systems; Cardiovascular System & Cardiology; Remote ischaemic preconditioning; microcirculation; endothelial function; cardiovascular risk; vascular adaptation; FLOW-MEDIATED DILATION; VASODILATOR FUNCTION; HUMANS; EXERCISE; MYOCARDIUM; INJURY
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: SAGE PUBLICATIONS LTD
Related URLs:
Date Deposited: 13 Jan 2016 12:53
Last Modified: 22 Jan 2016 10:07
DOI or Identification number: 10.1177/2047487314547657
URI: http://researchonline.ljmu.ac.uk/id/eprint/2581

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