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Effect of Resistance Training on Microvascular Density and eNOS Content in Skeletal Muscle of Sedentary Men

Cocks, MS and Shaw, CS and Shepherd, SO and Fisher, JP and Ranasinghe, AM and Barker, TA and Tipton, KD and Wagenmakers, AJM (2014) Effect of Resistance Training on Microvascular Density and eNOS Content in Skeletal Muscle of Sedentary Men. MICROCIRCULATION, 21 (8). pp. 738-746. ISSN 1073-9688

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Abstract

The effects of resistance training (RT) on muscle mass, strength and insulin sensitivity are well established, but the underlying mechanisms are only partially understood. The main aim of this study is to investigate whether RT induces changes in endothelial enzymes of the muscle microvasculature, which would increase NO bioavailability and could contribute to improved insulin sensitivity. Eight previously sedentary males (age 20±0.4y, BMI 24.5±0.9 kg.m-2) completed 6wk of RT 3x/week. Muscle biopsies were taken from the m. vastus lateralis and microvascular density and endothelial specific eNOS content, eNOS Ser1177 phosphorylation and NOX2 content were assessed pre- and post-RT using quantitative immunofluorescence microscopy. Whole body insulin sensitivity (measured as Matsuda Index), microvascular filtration capacity (functional measure of the total available endothelial surface area) and arterial stiffness (augmentation index, central and peripheral pulse wave velocity) were also measured. Measures of microvascular density, microvascular filtration capacity, microvascular eNOS content, basal eNOS phosphorylation and endothelial NOX2 content did not change from pre-RT to post-RT. RT increased insulin sensitivity (P <0.05) and reduced resting blood pressure and augmentation index (P <0.05), but did not change central or peripheral pulse wave velocity. In conclusion RT did not change any measure of muscle microvascular structure or function.

Item Type: Article
Additional Information: This is the peer reviewed version of the following article: Cocks M, Shaw CS, Shepherd SO, Fisher JP, Ranasinghe A, Barker TA, Tipton KD, Wagenmakers AJM. Effect of resistance training on microvascular density and eNOS content in skeletal muscle of sedentary men. Microcirculation 21: 738–746, 2014. which has been published in final form at http://dx.doi.org/10.1111/micc.12155 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving
Uncontrolled Keywords: 11 Medical And Health Sciences
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: WILEY-BLACKWELL
Related URLs:
Date Deposited: 18 Jan 2016 14:54
Last Modified: 18 Jan 2016 14:54
DOI or Identification number: 10.1111/micc.12155
URI: http://researchonline.ljmu.ac.uk/id/eprint/2668

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