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Impact of retrograde shear rate on brachial and superficial femoral artery flow-mediated dilation in older subjects

Schreuder, THA and Green, DJ and Hopman, MTE and Thijssen, DHJ (2015) Impact of retrograde shear rate on brachial and superficial femoral artery flow-mediated dilation in older subjects. ATHEROSCLEROSIS, 241 (1). pp. 199-204. ISSN 0021-9150

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Abstract

An inverse, dose-dependent relationship between retrograde shear rate and brachial artery endothelial function exists in young subjects. This relationship has not been investigated in older adults, who have been related to lower endothelial function, higher resting retrograde shear rate and higher risk of cardiovascular disease. Aim To investigate the impact of a step-wise increase in retrograde shear stress on flow-mediated dilation in older males in the upper and lower limbs. Methods Fifteen older (68±9 years) men reported to the laboratory 3 times. We examined brachial artery flow-mediated dilation before and after 30-minutes exposure to cuff inflation around the forearm at 0, 30 and 60 mmHg, to manipulate retrograde shear rate. Subsequently, the 30-minute intervention was repeated in the superficial femoral artery. Order of testing (vessel and intervention) was randomised. Results Increases in cuff pressure resulted in dose-dependent increases in retrograde shear in both the brachial and superficial femoral artery in older subjects. In both the brachial and the superficial femoral artery, no change in endothelial function in response to increased retrograde shear was observed in older males (‘time’ P=0.274, ‘cuff*time P=0.791’, ‘cuff*artery*time P=0.774’). Conclusion In contrast with young subjects, we found that acute elevation in retrograde shear rate does not impair endothelial function in older humans. This may suggest that subjects with a priori endothelial dysfunction are less responsive or requires a larger shear rate stimulus to alter endothelial function.

Item Type: Article
Uncontrolled Keywords: 1103 Clinical Sciences, 1102 Cardiovascular Medicine And Haematology
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Elsevier
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Date Deposited: 19 Jan 2016 15:06
Last Modified: 18 Apr 2016 23:50
DOI or Identification number: 10.1016/j.atherosclerosis.2015.04.017
URI: http://researchonline.ljmu.ac.uk/id/eprint/2685

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