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Elevation in blood flow and shear rate prevents hyperglycemia-induced endothelial dysfunction in healthy subjects and those with type 2 diabetes

Greyling, A and Schreuder, THA and Landman, T and Draijer, R and Verheggen, RJHM and Hopman, MTE and Thijssen, DHJ (2015) Elevation in blood flow and shear rate prevents hyperglycemia-induced endothelial dysfunction in healthy subjects and those with type 2 diabetes. JOURNAL OF APPLIED PHYSIOLOGY, 118 (5). pp. 579-585. ISSN 8750-7587

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ELEVATION IN BLOOD FLOW AND SHEAR RATE PREVENTS HYPERGLYCEMIA-INDUCED ENDOTHELIAL DYSFUNCTION IN HEALTHY AND TYPE 2 DIABETIC SUBJECTS.pdf - Accepted Version

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Abstract

Hyperglycemia, commonly present after a meal, causes transient impairment in endothelial function. We examined whether increases in blood flow (BF) protect against the hyperglycemia- mediated decrease in endothelial function in healthy subjects and patients with type 2 diabetes mellitus (T2DM). Ten healthy subjects and 10 age- and sex-matched T2DM patients underwent simultaneous bilateral assessment of brachial artery endothelial function by means of flow- mediated dilation (FMD), using high-resolution echo-Doppler. FMD was examined before and 60, 120 and 150 minutes after a 75-gr oral glucose challenge. We unilaterally manipulated BF by heating one arm between minute 30 and 60. Oral glucose administration caused a statistically significant, transient increase in blood glucose in both groups (P<0.001). Forearm skin temperature, brachial artery BF and shear rate significantly increased in the heated arm (P<0.001), and to a greater extent compared to the non-heated arm in both groups (interaction- effect, P<0.001). The glucose load caused a transient decrease in FMD% (P<0.05), whilst heating significantly prevented the decline (interaction-effect: P<0.01). Also when correcting for changes in diameter and shear rate, we found that the hyperglycemia-induced decrease in FMD can be prevented by local heating (P<0.05). These effects on FMD were observed in both groups. Our data indicate that non-metabolically driven elevation in BF and shear rate can similarly prevent the hyperglycemia-induced decline in conduit artery endothelial function in healthy volunteers and in patients with type 2 diabetes. Additional research is warranted to confirm that other interventions increasing BF and shear rate equally protect the endothelium when challenged by hyperglycemia.

Item Type: Article
Uncontrolled Keywords: 06 Biological Sciences, 11 Medical And Health Sciences
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: American Physiological Society
Related URLs:
Date Deposited: 10 Jun 2016 11:24
Last Modified: 10 Jun 2016 14:30
DOI or Identification number: 10.1152/japplphysiol.00936.2014
URI: http://researchonline.ljmu.ac.uk/id/eprint/2690

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