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Impact of prolonged sitting on vascular function in young girls

McManus, AM and Ainslie, PN and Green, DJ and Simair, RG and Smith, K and Lewis, N (2015) Impact of prolonged sitting on vascular function in young girls. Experimental Physiology, 100 (11). pp. 1379-1387. ISSN 1469-445X

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Abstract

Excessive sedentary behaviour has serious clinical and public health implications; however, the physiological changes that accompany prolonged sitting in the child are not completely understood. Herein, we examined the acute effect a prolonged period of sitting has upon superficial femoral artery function in 7- to 10-year-old girls and the impact of interrupting prolonged sitting with exercise breaks. Superficial femoral artery endothelium-dependent flow-mediated dilatation, total shear rate, anterograde and retrograde shear rates and oscillatory shear index were assessed before and after two experimental conditions: a 3 h uninterrupted period of sitting (SIT) and a 3 h period of sitting interrupted each hour with 10 min of moderate-intensity exercise (EX). A mixed-model analysis of variance was used to compare between-condition and within-condition main effects, controlling for the within-subject nature of the experiment by including random effects for participant. Superficial femoral artery endothelium-dependent flow-mediated dilatation decreased significantly from pre- to post-SIT (mean difference 2.2% flow-mediated dilatation; 95% confidence interval = 0.60–2.94%, P < 0.001). This relative decline of 33% was abolished in the EX intervention. Shear rates were not significantly different within conditions. Our data demonstrate the effectiveness of short but regular exercise breaks in offsetting the detrimental effects of uninterrupted sitting in young girls.

Item Type: Article
Additional Information: This is the peer reviewed version of the following article: McManus, A. M., Ainslie, P. N., Green, D. J., Simair, R. G., Smith, K. and Lewis, N. (2015), Impact of prolonged sitting on vascular function in young girls. Exp Physiol, 100: 1379–1387 which has been published in final form at [http://dx.doi.org/10.1113/EP085355 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving
Uncontrolled Keywords: 0606 Physiology, 1116 Medical Physiology, 1106 Human Movement And Sports Science
Subjects: Q Science > QP Physiology
R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Wiley
Related URLs:
Date Deposited: 20 Jan 2016 10:56
Last Modified: 07 Oct 2016 23:50
DOI or Identification number: 10.1113/EP085355
URI: http://researchonline.ljmu.ac.uk/id/eprint/2697

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