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Is the Soleus a Sentinel Muscle for Impaired Aerobic Capacity in Heart Failure?

Panizzolo, FA and Maiorana, AJ and Naylor, LH and Lichtwark, GA and Dembo, L and Lloyd, DG and Green, DJ and Rubenson, J (2015) Is the Soleus a Sentinel Muscle for Impaired Aerobic Capacity in Heart Failure? Medicine and Science in Sports and Exercise, 47 (3). pp. 498-508. ISSN 1530-0315

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Abstract

Purpose: Skeletal muscle wasting is well documented in chronic heart failure (CHF). This article provides a more detailed understanding of the morphology behind this muscle wasting and the relation between muscle morphology, strength, and exercise capacity in CHF. We investigated the effect of CHF on lower limb lean mass, detailed muscle–tendon architecture of the individual triceps surae muscles (soleus (SOL), medial gastrocnemius, and lateral gastrocnemius) and how these parameters relate to exercise capacity and strength.

Methods: Eleven patients with CHF and 15 age-matched controls were recruited. Lower limb lean mass was assessed by dual energy x-ray absorptiometry and the architecture of skeletal muscle and tendon properties by ultrasound. Plantarflexor strength was assessed by dynamometry.

Results: Patients with CHF exhibited approximately 25% lower combined triceps surae volume and physiological cross-sectional area (PCSA) compared with those of control subjects (P < 0.05), driven in large part by reductions in the SOL. Only the SOL volume and the SOL and medial gastrocnemius physiological cross-sectional area were statistically different between groups after normalizing to lean body mass and body surface area, respectively. Total lower limb lean mass did not differ between CHF and control subjects, further highlighting the SOL specificity of muscle wasting in CHF. Moreover, the volume of the SOL and plantarflexor strength correlated strongly with peak oxygen uptake (V˙O2peak) in patients with CHF.

Conclusions: These findings suggest that the SOL may be a sentinel skeletal muscle in CHF and provide a rationale for including plantarflexor muscle training in CHF care.

Item Type: Article
Additional Information: This is a non-final version of an article published in final form in Medicine & Science in Sports & Exercise: March 2015 - Volume 47 - Issue 3 - p 498–508 doi: 10.1249/MSS.0000000000000431
Uncontrolled Keywords: 1106 Human Movement And Sports Science
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: American College of Sports Medicine
Related URLs:
Date Deposited: 20 Jan 2016 11:39
Last Modified: 01 Mar 2016 00:50
DOI or Identification number: 10.1249/MSS.0000000000000431
URI: http://researchonline.ljmu.ac.uk/id/eprint/2699

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