Sarker, SD and Salleh, WMNHW and Ahmad, F and Yem, K and Zulkifli, MR (2016) Madangones A and B, two new neolignans from Beilschmiedia madang Blume and their bioactivities. Phytochemistry Letters, 15. pp. 168-173. ISSN 1876-7486
PHYTOL-D-15-00474_revised_SS.pdf - Accepted Version
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Two new neolignans, madangones A (1) and B (2), together with (+)-kunstlerone (3), vanillin, vanillic acid, betulin, β-sitosterol and β-sitostenone, were isolated from the stem bark of Beilschmiedia madang (Lauraceae). The structures of the compounds were determined by spectroscopic means. The compounds were tested for antioxidant, acetylcholinesterase inhibitory and anti-inflammatory activities. Compound (3) displayed the strongest DPPH radical-scavenging activity with an IC50 value of 68.7 M. Compound (2) exhibited the highest level of activity on the COX-2 model and acetylcholinesterase inhibition assay, with IC50 values of 27.4 and 70.3 µM, respectively.
|Uncontrolled Keywords:||0304 Medicinal And Biomolecular Chemistry, 0607 Plant Biology, 1115 Pharmacology And Pharmaceutical Sciences|
|Subjects:||R Medicine > RS Pharmacy and materia medica|
|Divisions:||Pharmacy & Biomolecular Sciences|
|Date Deposited:||29 Jan 2016 16:06|
|Last Modified:||15 Jan 2017 00:50|
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