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Synthesis and structure-activity-relationships of indan acid derivatives as analgesic and anti-inflammatory agents

Bachar, SC and Nahar, L and Sarker, SD (2016) Synthesis and structure-activity-relationships of indan acid derivatives as analgesic and anti-inflammatory agents. Review Journal of Chemistry, 6 (2). pp. 125-138. ISSN 2079-9799

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Abstract

Indan ring system, also known as indane or benzocyclopentane, is an important chemical feature associated with various biological activities. Among the drugs possessing an indan ring system, 1H-indene-3-acetic acid-5-fluoro-2-methyl-1-[4-(methylsulfinyl)-phenyl]methylene (Sulindac) and 6-chloro-5-cyclohexyl indan-1-carboxylic acid (Clidanac) are well known anti-inflammatory agents, whilst indan-1,3-dione is an anticoagulant. Over the years, several indan derivatives, particularly indan acid derivatives, have been synthesized and their potential analgesic and anti-inflammatory properties have been studied. This review critically appraises various synthetic protocols and structure-activity-relationships of indan acids as analgesic and anti-inflammatory agents with low ulcerogenicity.

Item Type: Article
Additional Information: The final publication is available at Springer via http://dx.doi.org/10.1134/S2079978016020011
Subjects: R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Springer Verlag
Date Deposited: 01 Feb 2016 12:19
Last Modified: 06 Sep 2017 17:42
DOI or Identification number: 10.1134/S2079978016020011
URI: http://researchonline.ljmu.ac.uk/id/eprint/2797

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