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Ferulone A and ferulone B: two new coumarin esters from Ferula orientalis L. roots, Natural Products Research

Razavi, SM and Nahar, L and Talichi, H and Sarker, SD (2016) Ferulone A and ferulone B: two new coumarin esters from Ferula orientalis L. roots, Natural Products Research. Natural Product Research. ISSN 1478-6419

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Abstract

Ferula orientalis (Apiaceae) is a well known perennial herb growing wild in Iran used in traditional medicine. To perform phytochemical studies, dried ground roots of F. orientalis were sequentially Soxhlet-extracted using n-hexane, dichloromethane and methanol. A combination of vacuum liquid chromatography and preparative thin layer chromatographic analyses were performed to isolate coumarin esters. The structures of the isolated compounds were elucidated by spectroscopic means, and in vitro free-radical-scavenging property was determined by the DPPH assay.Two new coumarin esters, 7-O-(4,8,12,16-tetrahydroxy-4,8,12,16-tetramethyl-heptadecanoyl)-coumarinand 7-O-(4-hydroxy-4,8,12-trimethyl-trideca-
7,11-dienoyl)-coumarin, named ferulone A and ferulone B, respectively, were isolated from the n-hexane extract of the roots of F. orientalis. Both compounds showed a low level of free-radical-scavenging property with the RC50 values of 0.252 and 0.556mg/mL for compounds 1 and 2, respectively, as opposed to that of the positive control (quercetin) 0.004 mg/mL. This is the first report on the purification of coumarin esters from the genus Ferula.

Item Type: Article
Additional Information: This is an Accepted Manuscript of an article published by Taylor & Francis in Natural Product Research on 18 Mar 2016 available online: http://wwww.tandfonline.com/10.1080/14786419.2016.1155574
Uncontrolled Keywords: MD Multidisciplinary
Subjects: Q Science > QK Botany
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Taylor & Francis
Date Deposited: 08 Feb 2016 10:11
Last Modified: 31 Mar 2016 10:44
DOI or Identification number: 10.1080/14786419.2016.1155574
URI: http://researchonline.ljmu.ac.uk/id/eprint/2851

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