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Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA)

Tollefsen, KE and Scholz, S and Cronin, MTD and Edwards, SW and de Knecht, J and Crofton, K and Garcia-Reyero, N and Hartung, T and Worth, A and Patlewicz, G (2014) Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA). REGULATORY TOXICOLOGY AND PHARMACOLOGY, 70 (3). pp. 629-640. ISSN 0273-2300

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Abstract

Chemical regulation is challenged by the large number of chemicals requiring assessment for potential human health and environmental impacts. Current approaches are too resource intensive in terms of time, money and animal use to evaluate all chemicals under development or already on the market. The need for timely and robust decision making demands that regulatory toxicity testing becomes more cost-effective and efficient. One way to realize this goal is by being more strategic in directing testing resources; focusing on chemicals of highest concern, limiting testing to the most probable hazards, or targeting the most vulnerable species. Hypothesis driven Integrated Approaches to Testing and Assessment (IATA) have been proposed as practical solutions to such strategic testing. In parallel, the development of the Adverse Outcome Pathway (AOP) framework, which provides information on the causal links between a molecular initiating event (MIE), intermediate key events (KEs) and an adverse outcome (AO) of regulatory concern, offers the biological context to facilitate development of IATA for regulatory decision making. This manuscript summarizes discussions at the Workshop entitled “Advancing AOPs for Integrated Toxicology and Regulatory Applications” with particular focus on the role AOPs play in informing the development of IATA for different regulatory purposes.

Item Type: Article
Uncontrolled Keywords: 1115 Pharmacology And Pharmaceutical Sciences
Subjects: Q Science > QD Chemistry
R Medicine > RA Public aspects of medicine > RA1190 Toxicology. Poisions
Divisions: Pharmacy & Biomolecular Sciences
Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE
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Date Deposited: 09 Feb 2016 10:46
Last Modified: 09 Feb 2016 10:46
DOI or Identification number: 10.1016/j.yrtph.2014.09.009
URI: http://researchonline.ljmu.ac.uk/id/eprint/2876

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