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Insight into inclusion complexation of indomethacin nicotinamide cocrystals

Ali, HRH and Saleem, IY and Tawfeek, HM (2016) Insight into inclusion complexation of indomethacin nicotinamide cocrystals. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 84 (3). pp. 179-188. ISSN 1388-3127

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Abstract

The objective of this research was to investigate the feasibility of the interaction between indomethacin-nicotinamide cocrystals with β-cyclodextrin and hydroxypropyl-β-cyclodextrin in the solid-state. The study has emphasized on the possibility of inclusion complex formation and its effect on the dissolution performance of the cocrystals. The solid systems in the molar ratio of 1:1 of the host and guest molecules were prepared by co-grinding and co-evaporation methods and compared with their physical mixtures. Furthermore, the molecular behaviors of the cocrystals in all prepared samples were thoroughly characterized by powder X-ray diffraction, differential scanning calorimetry, Fourier-transform infrared spectroscopy, scanning electron microscopy and in-vitro dissolution performance. The results of these studies indicated that complexes prepared by the co-evaporation method with hydroxypropyl-β-cyclodextrin have shown complete inclusion of the cocrystals into the cyclodextrin cavity and a partial inclusion with β-cyclodextrin. Moreover, a significant (p < 0.05; ANOVA/Tukey) higher in-vitro dissolution was achieved in co-evaporate complex prepared with hydroxypropyl-β-cyclodextrin compared to that prepared with β-cyclodextrin, indomethacin-nicotinamide cocrystals and indomethacin itself.

Item Type: Article
Additional Information: The final publication is available at Springer via http://dx.doi.org/10.1007/s10847-016-0594-3
Uncontrolled Keywords: 03 Chemical Sciences
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Springer
Date Deposited: 23 Aug 2016 09:05
Last Modified: 07 Sep 2017 13:16
DOI or Identification number: 10.1007/s10847-016-0594-3
URI: http://researchonline.ljmu.ac.uk/id/eprint/2971

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