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The individual and combined influence of ACE and ACTN3 genotypes on muscle phenotypes before and after strength training

Erskine, RM and Williams, AG and Jones, DA and Stewart, CE and Degens, H (2014) The individual and combined influence of ACE and ACTN3 genotypes on muscle phenotypes before and after strength training. SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS, 24 (4). pp. 642-648. ISSN 0905-7188

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Abstract

Alternative measures of muscle size, strength, and power to those used in previous studies could help resolve the controversy surrounding associations between polymorphisms of the angiotensin-I converting enzyme (ACE) and α-actinin-3 (ACTN3) genes and skeletal muscle phenotypes, and the responses to resistance training (RT). To this end, we measured quadriceps femoris muscle volume (Vm), physiological cross-sectional area (PCSA), maximum isometric force (Ft), specific force (Ft per unit PCSA), maximum isoinertial strength (1-RM), and maximum power (Wmax; n = 40) before and after 9-week knee extension RT in 51 previously untrained young men, who were genotyped for the ACE I/D and ACTN3 R577X polymorphisms. ACTN3 R-allele carriers had greater Vm, 1-RM, and Wmax than XX homozygotes at baseline (all P < 0.05), but responses to RT were independent of ACTN3 genotype (all P > 0.05). Muscle phenotypes were independent of ACE genotype before (all P > 0.05) and after RT (all P > 0.01). However, people with the “optimal” ACE+ACTN3 genotype combination had greater baseline 1-RM and Wmax compared to those with the “suboptimal” profile (both P < 0.0125). We show for the first time that the ACTN3 R577X polymorphism is associated with human Vm and (independently and in combination with the ACE I/D polymorphism) influences 1-RM and Wmax.

Item Type: Article
Additional Information: This is the peer reviewed version of the following article: Erskine, R. M., Williams, A. G., Jones, D. A., Stewart, C. E. and Degens, H. (2014), The individual and combined influence of ACE and ACTN3 genotypes on muscle phenotypes before and after strength training. Scandinavian Journal of Medicine & Science in Sports, 24: 642–648, which has been published in final form at http://dx.doi.org/10.1111/sms.12055 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Uncontrolled Keywords: 1106 Human Movement And Sports Science
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: WILEY-BLACKWELL
Related URLs:
Date Deposited: 26 Feb 2016 09:25
Last Modified: 26 Feb 2016 09:25
DOI or Identification number: 10.1111/sms.12055
URI: http://researchonline.ljmu.ac.uk/id/eprint/2994

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