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Tricyclic Cationic Chromophores as Models for New Photoantimicrobials

Wainwright, M (2015) Tricyclic Cationic Chromophores as Models for New Photoantimicrobials. JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 26 (12). pp. 2390-2404. ISSN 0103-5053

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Abstract

Despite the preponderance of literature pertaining to photosensitisers based on the porphyrin system, many other chemical classes are available with similar or improved characteristics and potential for use in photodynamic medicine. Several of these classes are based on small, tricyclic, heteroaromatic chromophores, often originally developed from textile dyes or biological stains. The latter classification is useful in providing a basis for biological uptake and antimicrobial activity. The current review covers the chemistry and photoantimicrobial applications of established and novel cationic bisamino derivatives of the acridine, phenazine, phenoxazine, phenothiazine and xanthene systems and related compounds. The range covered is considerable and demonstrates photodynamic performance to rival the porphyrin class. In addition, the chemical synthesis of new analogues of lead compounds such as methylene blue or acridine orange is relatively straightforward and inexpensive, and compound series with varying physicochemical profiles have been produced for structure-activity studies in order to furnish improved photosensitisers for clinical trialling

Item Type: Article
Uncontrolled Keywords: 03 Chemical Sciences
Subjects: R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Brazilian Chemical Society
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Date Deposited: 07 Mar 2016 09:36
Last Modified: 07 Mar 2016 09:36
DOI or Identification number: 10.5935/0103-5053.20150188
URI: http://researchonline.ljmu.ac.uk/id/eprint/3070

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