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ANALGESIC, ANTI-INFLAMMATORY AND ANTIPYRETIC ACTIVITIES OF THE AQUEOUS EXTRACT OF GERANIUM CAROLINIANUM L

Li, Y and Yeung, YW and Wang, S-J and Xia, W and Rahman, K and Yue, W and Zhang, H (2016) ANALGESIC, ANTI-INFLAMMATORY AND ANTIPYRETIC ACTIVITIES OF THE AQUEOUS EXTRACT OF GERANIUM CAROLINIANUM L. AFRICAN JOURNAL OF TRADITIONAL COMPLEMENTARY AND ALTERNATIVE MEDICINES, 13 (1). pp. 105-113. ISSN 0189-6016

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Analgesic, anti-inflammatory and antipyretic activities of the aqueous extract of Geranium carolinianum[1].pdf - Accepted Version

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Abstract

Background: Geranium carolinianum L. (Geraniaceae) is widely used for a variety of diseases including herpetic keratitis, eczema, rheumatalgia etc. However, there is lack of relevant scientific research.
Materials and Methods: GCE (125, 250, 500mg/kg body weight) was evaluated for its pharmacological properties by using the acetic acid-induced writhing test, the hot plate test and the fresh egg white-induced paw edema in rats. The dimethylbenzene-induced mouse inflammation model and the lipopolysaccharide (LPS)-induced rat fever model were employed and the acute toxicity of GCE was also assessed.
Results: The Geranium carolinianum aqueous extract (GCE) significantly inhibited the writhing responses in mice, increased reaction time of mice in the hot plate test, and suppressed the fresh egg white-induced paw edema in rats and the dimethylbenzene-induced ear edema in mice whilst attenuating LPS-induced fever in rats in a dose dependent manner. Furthermore, no deaths were observed when mice were orally administered GCE up to 14 g/kg body weight (approximately 553times of clinical dose).
Conclusions: GCE possesses analgesic, anti-inflammatory and antipyretic activities and is non-toxic at the doses used. The results of this study support the clinical use and effectiveness of Geranium carolinianum as an analgesic, anti-inflammatory and antipyretic agent in folk medicine.
Key words: Plant drug; Pain; Inflammation; Pyrexia; Toxicity; Animal

Item Type: Article
Uncontrolled Keywords: 1103 Clinical Sciences
Subjects: R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Divisions: Pharmacy & Biomolecular Sciences
Publisher: AFRICAN NETWORKS ETHNOMEDICINES
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Date Deposited: 30 Jun 2016 07:51
Last Modified: 01 Jan 2017 00:50
DOI or Identification number: 10.4314/ajtcam.v13i1.15
URI: http://researchonline.ljmu.ac.uk/id/eprint/3077

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