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Ameliorating effects of essential oil from Acori graminei rhizoma on learning and memory in aged rats and mice

Zhang, H and Han, T and Yu, C-H and Rahman, K and Qin, L-P and Peng, C (2007) Ameliorating effects of essential oil from Acori graminei rhizoma on learning and memory in aged rats and mice. JOURNAL OF PHARMACY AND PHARMACOLOGY, 59 (2). pp. 301-309. ISSN 0022-3573

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Abstract

Although there are normal cognitive changes that take place as a person becomes older, ageing in humans is generally associated with a deterioration of cognitive performance, in particular of learning and memory. There are a number of herbal medicines that are reported to improve brain function and intelligence. In the present study, the ameliorating effects of an essential oil extracted from Acori graminei rhizoma on learning and memory in aged, dysmnesia rats and mice were determined using the step-down passive avoidance test and Y maze. Oral administration of the essential oil (0.02, 0.04 and 0.08 g kg−1) to rats for 30 days and to mice for 15 days improved the latency and number of errors in aged, dysmnesia rats and mice. The cerebral neurotransmitters in aged rats given the essential oil (0.02, 0.04, 0.08 g kg−1) for 30 days were also investigated, and increased levels of norepinephrine, dopamine and serotonin, and decreased levels of acetylcholinesterase activity were found. The results suggest that the essential oil improves cognitive function in aged animals possibly by increasing norepinephrine, dopamine and serotonin relative levels, and by decreasing the activity of acetylcholinesterase in the cerebra.

Item Type: Article
Additional Information: This is the peer reviewed version of the following article: Zhang, H., Han, T., Yu, C.-H., Rahman, K., Qin, L.-P. and Peng, C. (2007), Ameliorating effects of essential oil from Acori graminei rhizoma on learning and memory in aged rats and mice. Journal of Pharmacy and Pharmacology, 59: 301–309, which has been published in final form at http://dx.doi.org/10.1211/jpp.59.2.0016. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving
Uncontrolled Keywords: 1115 Pharmacology And Pharmaceutical Sciences
Subjects: Q Science > QH Natural history > QH301 Biology
R Medicine > RS Pharmacy and materia medica
Divisions: Pharmacy & Biomolecular Sciences
Publisher: WILEY-BLACKWELL
Related URLs:
Date Deposited: 09 Mar 2016 13:51
Last Modified: 09 Mar 2016 13:51
DOI or Identification number: 10.1211/jpp.59.2.0016
URI: http://researchonline.ljmu.ac.uk/id/eprint/3128

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