Facial reconstruction

Search LJMU Research Online

Browse Repository | Browse E-Theses

Test purchase, synthesis and characterization of 3-fluorophenmetrazine (3-FPM) and differentiation from its ortho- and para-substituted isomers.

McLaughlin, G and Morris, N and Kavanagh, PV and Dowling, G and Power, JD and Twamley, B and O'Brien, J and Talbot, B and Sitte, HH and Brandt, SD (2016) Test purchase, synthesis and characterization of 3-fluorophenmetrazine (3-FPM) and differentiation from its ortho- and para-substituted isomers. Drug Testing and analysis. ISSN 1942-7611

[img] Text
DTA-15-0338.R1_accepted_uncorrected.pdf - Accepted Version

Download (1MB)
[img] Text (Supplementary Information)
DTA-15-0338.R1_SuppInfo[1].pdf - Supplemental Material

Download (1MB)

Abstract

The knowledge captured in patent and scientific research literature stimulates new ideas and fosters new drug development efforts. Manufacturers and entrepreneurs dedicated to the sale of 'research chemicals' and/or new psychoactive substances (NPS) also make use of access to information to identify, prepare, and launch a range of new substances. One of the most recent compounds to appear on the NPS market is the phenmetrazine analog 3-fluorophenmetrazine (3-FPM) which represents one of many phenylmorpholines designed to explore treatment options in areas such as obesity and drug dependence. The anorectic drug analogs phenmetrazine and phendimetrazine, used as prescription medicines before they were withdrawn, feature amphetamine-like properties associated with monoamine release. Available data on 3-FPM suggest that the effects might show mechanistic overlaps. This study describes the synthesis and extensive analytical characterization of 3-FPM and its differentiation from synthesized ortho- and para- substituted isomers, 2-FPM and 4-FPM, respectively. This study was triggered by the purchase of five powdered samples advertised as 3-FPM by five different Internet vendors based in the United Kingdom. The analytical data obtained for the vendor samples were consistent with the synthesized 3-FPM standard and differentiation between all three isomers was possible. The presence of positional isomers and the absence of suitable reference material can cause difficulties in the day-to-day operation of forensic work and given the rate at which many of the newly emerging NPS appear on the market, a comprehensive approach is needed when attempting to decipher the identity of NPS arriving onto the drug market. Copyright © 2016 John Wiley & Sons, Ltd.

Item Type: Article
Additional Information: This is the accepted version of the following article: "Test purchase, synthesis and characterization of 3-fluorophenmetrazine (3-FPM) and differentiation from its ortho- and para-substituted isomers", which has been published in final form at http://dx.doi.org/10.1002/dta.1945
Uncontrolled Keywords: 0301 Analytical Chemistry, 1115 Pharmacology And Pharmaceutical Sciences
Subjects: R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Wiley
Related URLs:
Date Deposited: 10 Mar 2016 10:08
Last Modified: 13 Sep 2017 16:27
DOI or Identification number: 10.1002/dta.1945
URI: http://researchonline.ljmu.ac.uk/id/eprint/3143

Actions (login required)

View Item View Item