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Impact of an endurance training program on exercise-induced cardiac biomarker release

Legaz-Arrese, A and Lopez-Laval, I and George, KP and Puente-Lanzarote, JJ and Mayolas-Pi, C and Serrano-Ostariz, E and Revilla-Marti, P and Moliner-Urdiales, D and Reverter-Masia, J (2015) Impact of an endurance training program on exercise-induced cardiac biomarker release. AMERICAN JOURNAL OF PHYSIOLOGY - HEART AND CIRCULATORY PHYSIOLOGY, 308 (8). H913-H920. ISSN 0363-6135

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Abstract

We evaluated the influence of a 14-wk endurance running program on the exercise-induced release of high-sensitivity cardiac troponin T (hs-cTnT) and NH2-terminal pro-brain natriuretic peptide (NT-proBNP). Fifty-eight untrained participants were randomized to supervised endurance exercise (14 wk, 3–4 days/wk, 120–240 min/wk, 65–85% of maximum heart rate) or a control group. At baseline and after the training program, hs-cTnT and NT-proBNP were assessed before and 5 min, 1 h, 3 h, 6 h, 12 h, and 24 h after a 60-min maximal running test. Before training, hs-cTnT was significantly elevated in both groups with acute exercise (P < 0.0001) with no between-group differences. There was considerable heterogeneity in peak hs-cTnT concentration with the upper reference limit exceeded in 71% of the exercise tests. After training, both baseline and postexercise hs-cTnT were significantly higher compared with pretraining and the response of the control group (P = 0.008). Acute exercise led to a small but significant increase in NT-proBNP, but this was not mediated by training (P = 0.121). In summary, a controlled endurance training intervention resulted in higher pre- and postexercise values of hs-cTnT with no changes in NT-proBNP.

Item Type: Article
Uncontrolled Keywords: 0606 Physiology, 1116 Medical Physiology
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: American Physiological Society
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Date Deposited: 11 Mar 2016 14:31
Last Modified: 15 Apr 2016 23:50
DOI or Identification number: 10.1152/ajpheart.00914.2014
URI: http://researchonline.ljmu.ac.uk/id/eprint/3172

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