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MRSI-based molecular imaging of therapy response to temozolomide in preclinical glioblastoma using source analysis

Delgado-Goñi, T and Ortega Martorell, S and Ciezka, M and Olier, I and Candiota, AP and Julià-Sapé, M and Fernández, F and Pumarola, M and Lisboa, P and Arús, C (2016) MRSI-based molecular imaging of therapy response to temozolomide in preclinical glioblastoma using source analysis. NMR in Biomedicine, 29 (6). pp. 732-743. ISSN 1099-1492

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Abstract

Characterization of Gliobastoma (GB) response to treatment is a key factor for improving patient's survival and prognosis. Magnetic resonance Imaging and Spectroscopic Imaging (MRI/MRSI) provide morphologic and metabolic profiles of GB but usually fail to produce unequivocal biomarkers of response. The purpose of this work is to provide proof-of-concept of the capability of a semi-supervised signal source extraction methodology to produce images with robust recognition of response to temozolomide (TMZ) in a preclinical GB model.

Item Type: Article
Additional Information: This is the accepted version of the following article: "MRSI-based molecular imaging of therapy response to temozolomide in preclinical glioblastoma using source analysis", which has been published in final form at http://dx.doi.org/10.1002/nbm.3521
Uncontrolled Keywords: 1103 Clinical Sciences, 0304 Medicinal And Biomolecular Chemistry, 0903 Biomedical Engineering
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Applied Mathematics
Publisher: Wiley
Date Deposited: 17 Mar 2016 09:25
Last Modified: 07 Oct 2016 10:53
DOI or Identification number: 10.1002/nbm.3521
URI: http://researchonline.ljmu.ac.uk/id/eprint/3282

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