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Application of in silico and in vitro methods in the development of adverse outcome pathway constructs in wildlife

Madden, JC and Rogiers, V and Vinken, M (2014) Application of in silico and in vitro methods in the development of adverse outcome pathway constructs in wildlife. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 369 (1656). ISSN 0962-8436

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Abstract

There is a long history of using both in silico and in vitro methods to predict adverse effects in humans and environmental species where toxicity data are lacking. Currently, there is a great deal of interest in applying these methods to the development of so-called ‘adverse outcome pathway’ (AOP) constructs. The AOP approach provides a framework for organizing information at the chemical and biological level, allowing evidence from both in silico and in vitro studies to be rationally combined to fill gaps in knowledge concerning toxicological events. Fundamental to this new paradigm is a greater understanding of the mechanisms of toxicity and, in particular, where these mechanisms may be conserved across taxa, such as between model animals and related wild species. This presents an opportunity to make predictions across diverse species, where empirical data are unlikely to become available as is the case for most species of wildlife.

Item Type: Article
Uncontrolled Keywords: 06 Biological Sciences, 11 Medical And Health Sciences
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QL Zoology
R Medicine > RA Public aspects of medicine > RA1190 Toxicology. Poisions
Divisions: Pharmacy & Biomolecular Sciences
Publisher: ROYAL SOCIETY
Related URLs:
Date Deposited: 21 Mar 2016 13:47
Last Modified: 21 Mar 2016 13:47
DOI or Identification number: 10.1098/rstb.2013.0584
URI: http://researchonline.ljmu.ac.uk/id/eprint/3306

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