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Dissolution Enhancement and Formulation of Rapid-Release Lornoxicam Mini-Tablets

Tawfeek, HM and Saleem, IY and Roberts, M (2014) Dissolution Enhancement and Formulation of Rapid-Release Lornoxicam Mini-Tablets. JOURNAL OF PHARMACEUTICAL SCIENCES, 103 (8). pp. 2470-2483. ISSN 0022-3549

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Abstract

The aim was to enhance the dissolution of lornoxicam (LOR) and to produce mini-tablets with an optimised system to provide a rapid-release multi-particulate formulation. LOR systems were prepared through co-evaporation with either polyethylene glycol 6000 or Pluronic® F-68 (PLU) and adsorption onto Neusilin® US2 alone or co-adsorption in the presence of different amounts of polysorbate 80. All systems were characterised by FT-IR, differential scanning calorimetry, X-ray diffraction, flowability and dissolution techniques. Mini-tablets were prepared using the system with the optimum dissolution profile and flowability. Tensile strengths, content uniformity and dissolution profiles of the mini-tablets were evaluated. The effects of different excipients and storage conditions on mini-tablet properties were also studied. The optimised rapid-release LOR mini-tablets were further evaluated for their in vivo pharmacokinetic profile. The co-evaporate of LOR with PLU showed significantly faster dissolution and superior flowability and was evaluated together with three directly compressible excipients (Cellactose® 80, StarLac® (STA) and Emcompress®) for mini-tablet formulation. The formulation with STA provided the optimum results in terms of tensile strength content uniformity and rapid drug release following a 3-month stability study and was selected for further in vivo evaluation. The pharmacokinetic profile indicated the potential of the mini-tablets achieving rapid release and increased absorption of LOR

Item Type: Article
Uncontrolled Keywords: 1115 Pharmacology And Pharmaceutical Sciences
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Pharmacy & Biomolecular Sciences
Publisher: WILEY-BLACKWELL
Related URLs:
Date Deposited: 19 Apr 2016 13:53
Last Modified: 19 Apr 2016 14:15
DOI or Identification number: 10.1002/jps.24073
URI: http://researchonline.ljmu.ac.uk/id/eprint/3450

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