Meireles, S and De Groote, F and Reeves, ND and Verschueren, S and Maganaris, CN and Luyten, F and Jonkers, I (2016) Knee contact forces are not altered in early knee osteoarthritis. Gait and Posture, 45. pp. 115-120. ISSN 1879-2219
Meireles et al 2016 Gait Posture.pdf - Accepted Version
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OBJECTIVE: This study calculated knee contact forces (KCF) and its relations with knee external knee adduction moments (KAM) and/or flexion moments (KFM) during the stance phase of gait in patients with early osteoarthritis (OA), classified based on early joint degeneration on Magnetic Resonance Imaging (MRI). We aimed at assessing if altered KCF are already present in early structural degeneration. DESIGN: Three-dimensional motion and ground reaction force data in 59 subjects with medial compartment knee OA (N=23 established OA, N=16 early OA, N=20 controls) were used as input for a musculoskeletal model. KAM and KFM, and KCF were estimated using OpenSim software. RESULTS: No significant differences were found between controls and subjects with early OA. In early OA patients, KAM significantly explained 69% of the variance associated with the first peaks KCF but only KFM contributed to the second peaks KCF. The multiple correlation, combining KAM and KFM, showed to be higher. However, only 20% of the variance of second peak KCF was explained by both moments in established OA. CONCLUSION: KCF are not increased in patients with early OA, suggesting that knee joint overload is more a consequence of further joint degeneration in more advanced stages of OA. Additionally, our results clearly show that KAM is not sufficient to predict joint loading at the end of the stance, where KFM contributes substantially to the loading, especially in early OA.
|Uncontrolled Keywords:||1103 Clinical Sciences, 1106 Human Movement And Sports Science, 0913 Mechanical Engineering|
|Subjects:||R Medicine > RC Internal medicine > RC1200 Sports Medicine|
|Divisions:||Sport & Exercise Sciences|
|Date Deposited:||19 Apr 2016 14:14|
|Last Modified:||25 Jan 2017 00:50|
|DOI or Identification number:||10.1016/j.gaitpost.2016.01.016|
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