Ward, DD and Summers, MJ and Saunders, NL and Ritchie, K and Summers, JJ and Vickers, JC (2015) The BDNF Val66Met polymorphism moderates the relationship between cognitive reserve and executive function. TRANSLATIONAL PSYCHIATRY, 5. e590-e590. ISSN 2158-3188
The BDNF Val66Met polymorphism moderates the relationship between cognitive reserve and executive function.pdf - Published Version
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The concept of cognitive reserve (CR) has been proposed to account for observed discrepancies between pathology and its clinical manifestation due to underlying differences in brain structure and function. In 433 healthy older adults participating in the Tasmanian Healthy Brain Project, we investigated whether common polymorphic variations in apolipoprotein E (APOE) or brain-derived neurotrophic factor (BDNF) influenced the association between CR contributors and cognitive function in older adults. We show that BDNF Val66Met moderates the association between CR and executive function. CR accounted for 8.5% of the variance in executive function in BDNF Val homozygotes, but CR was a nonsignificant predictor in BDNF Met carriers. APOE polymorphisms were not linked to the influence of CR on cognitive function. This result implicates BDNF in having an important role in capacity for building or accessing CR.
|Uncontrolled Keywords:||Science & Technology; Life Sciences & Biomedicine; Psychiatry; HEALTHY BRAIN PROJECT; ALZHEIMERS-DISEASE; OLDER-ADULTS; ENVIRONMENTAL ENRICHMENT; APOLIPOPROTEIN-E; LIFE-STYLE; SYNAPTIC PLASTICITY; CORTICAL PLASTICITY; DEMENTIA RISK; MEMORY|
|Subjects:||R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
R Medicine > RC Internal medicine > RC1200 Sports Medicine
|Divisions:||Sport & Exercise Sciences|
|Publisher:||NATURE PUBLISHING GROUP|
|Date Deposited:||20 Apr 2016 09:00|
|Last Modified:||20 Apr 2016 09:00|
|DOI or Identification number:||10.1038/tp.2015.82|
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