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The BDNF Val66Met polymorphism moderates the relationship between cognitive reserve and executive function

Ward, DD and Summers, MJ and Saunders, NL and Ritchie, K and Summers, JJ and Vickers, JC (2015) The BDNF Val66Met polymorphism moderates the relationship between cognitive reserve and executive function. TRANSLATIONAL PSYCHIATRY, 5. e590-e590. ISSN 2158-3188

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Abstract

The concept of cognitive reserve (CR) has been proposed to account for observed discrepancies between pathology and its clinical manifestation due to underlying differences in brain structure and function. In 433 healthy older adults participating in the Tasmanian Healthy Brain Project, we investigated whether common polymorphic variations in apolipoprotein E (APOE) or brain-derived neurotrophic factor (BDNF) influenced the association between CR contributors and cognitive function in older adults. We show that BDNF Val66Met moderates the association between CR and executive function. CR accounted for 8.5% of the variance in executive function in BDNF Val homozygotes, but CR was a nonsignificant predictor in BDNF Met carriers. APOE polymorphisms were not linked to the influence of CR on cognitive function. This result implicates BDNF in having an important role in capacity for building or accessing CR.

Item Type: Article
Uncontrolled Keywords: Science & Technology; Life Sciences & Biomedicine; Psychiatry; HEALTHY BRAIN PROJECT; ALZHEIMERS-DISEASE; OLDER-ADULTS; ENVIRONMENTAL ENRICHMENT; APOLIPOPROTEIN-E; LIFE-STYLE; SYNAPTIC PLASTICITY; CORTICAL PLASTICITY; DEMENTIA RISK; MEMORY
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: NATURE PUBLISHING GROUP
Related URLs:
Date Deposited: 20 Apr 2016 09:00
Last Modified: 07 Sep 2017 13:18
DOI or Identification number: 10.1038/tp.2015.82
URI: http://researchonline.ljmu.ac.uk/id/eprint/3459

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