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Beilschglabrines A and B: Two new bioactive phenanthrene alkaloids from the stem bark of Beilschmiedia glabra

Salleh, WMNHW and Ahmad, F and Khong, HY and Zulkifli, RM and Chen, JJ and Nahar, L and Wansi, JD and Sarker, SD (2016) Beilschglabrines A and B: Two new bioactive phenanthrene alkaloids from the stem bark of Beilschmiedia glabra. Phytochemistry Letters, 16. pp. 192-196. ISSN 1874-3900

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Abstract

Two new phenanthrene alkaloids, beilschglabrines A (1) and B (2) were isolated from the stem bark of Beilschmiedia glabra, together with lupeol, taraxerol, and 24-methylenelanosta-7,9-diene-3β-15α-diol. The structures of the isolated compounds were elucidated by extensive spectroscopic data analysis and comparison with respective literature data. The compounds were tested for DPPH radical scavenging, acetylcholinesterase and lipoxygenase inhibitory activities. Compound 1 displayed considerable activity in the acetylcholinesterase (IC50 50.4 μM), the DPPH radical scavenging (IC50 115.9 μM) and the lipoxygenase (IC50 32.8 μM) assays. © 2016 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

Item Type: Article
Uncontrolled Keywords: 0304 Medicinal And Biomolecular Chemistry, 0607 Plant Biology, 1115 Pharmacology And Pharmaceutical Sciences
Subjects: Q Science > QD Chemistry
R Medicine > RM Therapeutics. Pharmacology
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Elsevier
Date Deposited: 16 May 2016 10:09
Last Modified: 16 May 2016 10:09
DOI or Identification number: 10.1016/j.phytol.2016.04.013
URI: http://researchonline.ljmu.ac.uk/id/eprint/3608

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