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Tight control of disease activity fails to improve body composition or physical function in rheumatoid arthritis patients

Lemmey, AB and Wilkinson, T and Clayton, B and Sheikh, F and Whale, J and Jones, H and Ahmed, Y and Chitale, S and Jones, J and Maddison, PJ and O'Brien, TD (2016) Tight control of disease activity fails to improve body composition or physical function in rheumatoid arthritis patients. Rheumatology. ISSN 1462-0332

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Abstract

Objective. RA typically features “rheumatoid cachexia” (loss of muscle mass (MM) and excessive fat mass (FM), especially trunk FM), which contributes to physical disability. Since rheumatoid cachexia is driven by inflammation, it would be anticipated that the success of tight control of disease activity, such as “treat-to-target” (T2T), in attenuating inflammation would benefit body composition and physical function. This cross-sectional study assessed the impact of T2T on body composition and objectively-assessed function in RA patients.

Item Type: Article
Additional Information: This article has been accepted for publication in Rheumatology © 2016 The Author Published by Oxford University Press on behalf of the British society for Rheumatology. All rights reserved.
Uncontrolled Keywords: 1103 Clinical Sciences, 1107 Immunology, 1117 Public Health And Health Services
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Oxford University Press (OUP): Policy B - Oxford Open Option B
Date Deposited: 20 May 2016 08:36
Last Modified: 19 Jul 2016 09:57
DOI or Identification number: 10.1093/rheumatology/kew243
URI: http://researchonline.ljmu.ac.uk/id/eprint/3611

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