Abdul Sultan, A and West, J and Ban, L and Humes, D and Tata, LJ and Fleming, KM and Nelson-Piercy, C and Card, T (2016) Adverse Pregnancy Outcomes Among Women with Inflammatory Bowel Disease: A Population-Based Study from England. Inflammatory Bowel Diseases, 22 (7). pp. 1621-1630. ISSN 1536-4844
IBD_preg_comp01Feb2016.pdf - Accepted Version
Restricted to Repository staff only until 7 June 2017.
BACKGROUND: There is limited contemporary population-based evidence on adverse birth outcomes and pregnancy-related complications for women with inflammatory bowel disease (IBD). This study provides such estimates of these risks and assesses variation by IBD type and surgical interventions. METHODS: We calculated the proportion of pregnancies in women with and without IBD between 1997 and 2012 throughout England using linked primary (Clinical Practice Research Datalink) and secondary care (Hospital Episode Statistics) data. Risk of pregnancy-related complications and adverse birth outcomes in women with Crohn's disease and ulcerative colitis were compared with risks in women without IBD using odds ratios (ORs). RESULTS: Of 364,363 singleton pregnancies resulting in live or stillbirths, 1969 (0.5%) were in women with IBD. Women with Crohn's disease were more likely to have preterm births (OR = 1.42; 95% confidence interval, 1.12-1.79), babies with low birth weights (OR = 1.39; 95% confidence interval, 1.05-1.83), and postpartum hemorrhage (OR = 1.27; 95% confidence interval, 1.04-1.55), whereas women with ulcerative colitis were only at increased risk of preterm births with an absolute risk difference of <2.7%. These risks remained independent of caesarean section. Prior surgery for IBD did not increase the risk of adverse birth outcomes or pregnancy-related complications compared with cases without surgery, however, women with IBD were more likely to have an elective caesarean section. CONCLUSIONS: Women with Crohn's disease have increased risks of some specific pregnancy-related complications and adverse birth outcomes which are independent of caesarean section, however, the absolute risk differences are small, indicating that most women with IBD will have an uncomplicated pregnancy.
|Additional Information:||This is the accepted version of the following article: "Adverse Pregnancy Outcomes Among Women with Inflammatory Bowel Disease: A Population-Based Study from England", which has been published in final form at http://dx.doi.org/10.1097/MIB.0000000000000802|
|Uncontrolled Keywords:||1103 Clinical Sciences|
|Subjects:||R Medicine > RG Gynecology and obstetrics|
|Divisions:||Public Health Institute|
|Date Deposited:||02 Aug 2016 13:11|
|Last Modified:||02 Aug 2016 13:11|
|DOI or Identification number:||10.1097/MIB.0000000000000802|
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