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State-dependent alterations in CSF Abeta42 levels in cognitively intact elderly with late life major depression

Pomara, N and Bruno, D and Osorio, R and Reichert, C and Nierenberg, J and Sarreal, A and Hernando, R and Marmar, C and Wisniewski, T and Zetterberg, H and Blennow, K (2016) State-dependent alterations in CSF Abeta42 levels in cognitively intact elderly with late life major depression. Neuroreport, 27 (14). pp. 1068-1071. ISSN 1473-558X

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Abstract

Depression has been linked to Alzheimer’s disease (AD) as either an increased risk factor for its development or as a prodromal symptom. The neurobiological basis for such association, however, remains poorly understood. Numerous studies have examined whether changes in amyloid beta (Aβ) metabolism, which are implicated in AD pathogenesis, are also found in depression. In this paper, we investigated the relationship between depressive symptoms and cerebrospinal fluid (CSF) Aβ indices, in healthy cognitively normal elderly with late-life major depression (LLMD) and controls, by using a longitudinal approach, which is a novel contribution to the literature. Significantly lower levels of CSF Aβ42 were observed in the LLMD group at baseline and were associated with more severe depressive symptoms. During longitudinal follow up, the depressed group remained cognitively unchanged, but was significantly less depressed than at baseline. A greater improvement in depressive symptoms was associated with increases in CSF Aβ42 levels in both groups. Increases in CSF Aβ42 and Aβ40 were also associated with increased CSF total tau levels. Our results suggest that LLMD may be associated with state-dependent effects of CSF Aβ42 levels. Future studies should determine if the association reflects state-dependent changes in neuronal activity and/or brain amyloid burden in depression.

Item Type: Article
Additional Information: This is not the final published version
Uncontrolled Keywords: 1109 Neurosciences, 1702 Cognitive Science
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Natural Sciences and Psychology
Publisher: Lippincott, Williams & Wilkins
Date Deposited: 14 Jul 2016 12:58
Last Modified: 22 Jun 2017 09:52
DOI or Identification number: 10.1097/WNR.0000000000000658
URI: http://researchonline.ljmu.ac.uk/id/eprint/3890

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