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The impact of remote ischemic preconditioning on cardiac biomarker and functional response to endurance exercise.

Cocking, S and Landman, T and Benson, M and Lord, R and Jones, H and Gaze, D and Thijssen, DHJ and George, KP (2016) The impact of remote ischemic preconditioning on cardiac biomarker and functional response to endurance exercise. Scandinavian Journal of Medicine and Science in Sports. ISSN 1600-0838

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Abstract

Remote ischemic preconditioning (RIPC; repeated short reversible periods of ischemia) protects the heart against subsequent ischemic injury. We explored whether RIPC can attenuate post-exercise changes in cardiac troponin T (cTnT) and cardiac function in healthy individuals. In a randomized, crossover design, 14 participants completed 1-h cycling time trials (TT) on two separate visits; preceded by RIPC (arms/legs, 4 × 5-min 220 mmHg), or SHAM-RIPC (20 mmHg). Venous blood was sampled before and 0-, 1-, and 3-h post-exercise to assess high sensitivity (hs-)cTnT and brain natriuretic peptide (NT-proBNP). Echocardiograms were performed at the same time points to assess left and right ventricular systolic (ejection fraction; EF and right ventricular fractional area change; RVFAC, respectively) and diastolic (early transmitral flow velocities; E) function. Baseline hs-cTnT was not different between RIPC and SHAM. Post-exercise hs-cTnT levels were consistently lower following RIPC (18 ± 3 vs 21 ± 3; 19 ± 3 vs 23 ± 3; and 20 ± 2 vs 25 ± 2 ng/L at 0, 1 and 3-h post-exercise, respectively; P < 0.05). There was no main effect of time, trial, or interaction for NT-proBNP and left ventricular EF or RVFAC (all P < 0.05). A main effect of time was evident for E which transiently declined immediately after exercise to a similar level in both trials (0.85 ± 0.04 vs 0.74 ± 0.04 m/s, respectively; P < 0.05). In summary, RIPC was associated with lower hs-cTnT levels after exercise but there was no independent effect of RIPC for NT-proBNP or LV systolic and diastolic function. The lower hs-cTnT levels after RIPC suggests that further research should evaluate the role of ischemia in exercise-induced elevation in hs-cTnT.

Item Type: Article
Additional Information: This is the accepted version of the following article:Cocking, S., Landman, T., Benson, M., Lord, R., Jones, H., Gaze, D., Thijssen, D. H. J. and George, K. (2016), The impact of remote ischemic preconditioning on cardiac biomarker and functional response to endurance exercise. Scandinavian Journal of Medicine & Science in Sports. doi: 10.1111/sms.12724, which has been published in final form at http://dx.doi.org/10.1111/sms.12724
Uncontrolled Keywords: 1106 Human Movement And Sports Science
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Wiley
Related URLs:
Date Deposited: 27 Jul 2016 08:24
Last Modified: 19 Jul 2017 23:50
DOI or Identification number: 10.1111/sms.12724
URI: http://researchonline.ljmu.ac.uk/id/eprint/3946

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