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Construction and Evaluation of Rodent-Specific rTMS Coils

Tang, AD and Lowe, AS and Garrett, AR and Woodward, R and Bennett, W and Canty, AJ and Garry, MI and Hinder, MR and Summers, JJ and Gersner, R and Rotenberg, A and Thickbroom, G and Walton, J and Rodger, J (2016) Construction and Evaluation of Rodent-Specific rTMS Coils. FRONTIERS IN NEURAL CIRCUITS, 10. ISSN 1662-5110

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Abstract

Rodent models of transcranial magnetic stimulation (TMS) play a crucial role in aiding the understanding of the cellular and molecular mechanisms underlying TMS induced plasticity. Rodent-specific TMS have previously been used to deliver focal stimulation at the cost of stimulus intensity (12 mT). Here we describe two novel TMS coils designed to deliver repetitive TMS (rTMS) at greater stimulation intensities whilst maintaining spatial resolution. Two circular coils (8 mm outer diameter) were constructed with either an air or pure iron-core. Peak magnetic field strength for the air and iron-cores were 90 and 120 mT, respectively, with the iron-core coil exhibiting less focality. Coil temperature and magnetic field stability for the two coils undergoing rTMS, were similar at 1 Hz but varied at 10 Hz. Finite element modeling of 10 Hz rTMS with the iron-core in a simplified rat brain model suggests a peak electric field of 85 and 12.7 V/m, within the skull and the brain, respectively. Delivering 10 Hz rTMS to the motor cortex of anaesthetized rats with the iron-core coil significantly increased motor evoked potential amplitudes immediately after stimulation (n D 4). Our results suggest these novel coils generate modest magnetic and electric fields, capable of altering cortical excitability and provide an alternative method to investigate the mechanisms underlying rTMS-induced plasticity in an experimental setting.

Item Type: Article
Additional Information: This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permission.
Uncontrolled Keywords: Science & Technology; Life Sciences & Biomedicine; Neurosciences; Neurosciences & Neurology; rTMS; rodent models; magnetic field; electric field; motor evoked potentials; TRANSCRANIAL MAGNETIC STIMULATION; ELECTRIC-FIELD; AUDITORY-THRESHOLDS; ACTIVITY MARKERS; PLASTICITY; NEURONS; CORTEX; FREQUENCIES; MODULATION; FOCALITY
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Sport & Exercise Sciences
Publisher: FRONTIERS MEDIA SA
Related URLs:
Date Deposited: 23 Aug 2016 11:10
Last Modified: 23 Aug 2016 11:10
DOI or Identification number: 10.3389/fncir.2016.00047
URI: http://researchonline.ljmu.ac.uk/id/eprint/4054

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