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Ebola in great apes – current knowledge, possibilities for vaccination and the implications for conservation and human health

Leendertz, SAJ and Wich, SA and Ancrenaz, M and Bergl, RA and Gonder, MK and Humle, T and Leendertz, FH (2017) Ebola in great apes – current knowledge, possibilities for vaccination and the implications for conservation and human health. Mammal Review, 47 (2). pp. 98-111. ISSN 1365-2907

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Abstract

Ebola virus disease (EVD) is a threat to human health and the survival of African great apes. The disease has led to major population declines of chimpanzees and gorillas, and infected great apes play an important role as sources of human EVD outbreaks. The threat posed by EVD raises the question whether vaccination of wild apes is a possible strategy to reduce the occurence and impact of this disease.
This article reviews the current knowledge about EVD in great apes and emphasizes the link between ape and human outbreaks. It discusses the need for control strategies such as vaccination and describes aspects of primate behavior, virus biology, vaccine composition, and vaccination principles that are necessary to consider when making management decisions about great ape vaccination. Finally, it identifies gaps in the understanding of Ebola ecology and highlights surveillance and research that can aid the survival of great apes and reduce human exposure to Ebola virus.
The unpredictable emergence of Ebola viruses and the severe impact of EVD call for efficient monitoring and ultimately control of Ebola. This article provides a platform for further interdiciplinary discussions to decide on optimal management solutions regarding vaccination of great apes against Ebola.

Item Type: Article
Additional Information: This is the accepted version of the following article: Leendertz, S. A. J., Wich, S. A., Ancrenaz, M., Bergl, R. A., Gonder, M. K., Humle, T. and Leendertz, F. H. (2017), Ebola in great apes – current knowledge, possibilities for vaccination, and implications for conservation and human health. Mam Rev, 47: 98–111. doi:10.1111/mam.12082, which has been published in final form at http://dx.doi.org/10.1111/mam.12082
Uncontrolled Keywords: 0608 Zoology, 0602 Ecology
Subjects: Q Science > QH Natural history
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
R Medicine > RM Therapeutics. Pharmacology
Divisions: Natural Sciences and Psychology
Publisher: Wiley
Date Deposited: 11 Nov 2016 14:49
Last Modified: 10 May 2017 10:43
DOI or Identification number: 10.1111/mam.12082
URI: http://researchonline.ljmu.ac.uk/id/eprint/4098

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