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Advanced nanostructured medical device combining mesenchymal cells and VEGF nanoparticles for enhanced engineered tissue vascularization.

Wagner, Q and Offner, D and Idoux-Gillet, Y and Saleem, IY and Somavarapu, S and Schwinté, P and Benkirane-Jessel, N and Keller, L (2016) Advanced nanostructured medical device combining mesenchymal cells and VEGF nanoparticles for enhanced engineered tissue vascularization. Nanomedicine (Lond), 11 (18). pp. 2419-2430. ISSN 1743-5889

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Abstract

AIM: Success of functional vascularized tissue repair depends on vascular support system supply and still remains challenging. Our objective was to develop a nanoactive implant enhancing endothelial cell activity, particularly for bone tissue engineering in the regenerative medicine field. MATERIALS & METHODS: We developed a new strategy of tridimensional implant based on cell-dependent sustained release of VEGF nanoparticles. These nanoparticles were homogeneously distributed within nanoreservoirs onto the porous scaffold, with quicker reorganization of endothelial cells. Moreover, the activity of this active smart implant on cells was also modulated by addition of osteoblastic cells. RESULTS & CONCLUSION: This sophisticated active strategy should potentiate efficiency of current therapeutic implants for bone repair, avoiding the need for bone substitutes.

Item Type: Article
Additional Information: Advanced nanostructured medical device combining mesenchymal cells and VEGF nanoparticles for enhanced engineered tissue vascularization. Quentin Wagner, Damien Offner, Ysia Idoux-Gillet, Imran Saleem, Satyanarayana Somavarapu, Pascale Schwinté, Nadia Benkirane-Jessel, and Laetitia Keller. Nanomedicine, September 2016 ,Vol. 11, No. 18 , Pages 2419-2430 (doi: 10.2217/nnm-2016-0189)
Uncontrolled Keywords: 1004 Medical Biotechnology, 1007 Nanotechnology
Subjects: Q Science > QR Microbiology
R Medicine > RS Pharmacy and materia medica
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Future Medicine
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Date Deposited: 14 Sep 2016 08:44
Last Modified: 13 Sep 2017 02:18
DOI or Identification number: 10.2217/nnm-2016-0189
URI: http://researchonline.ljmu.ac.uk/id/eprint/4144

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