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Effect of a siderophore producer on animal cell apoptosis: a possible role as anti-cancer agent.

Nakouti, I and Sihanonth, P and Palaga, T and Hobbs, G (2013) Effect of a siderophore producer on animal cell apoptosis: a possible role as anti-cancer agent. International Journal of Pharma Medicine and Biological Sciences, 2 (3). pp. 1-5. ISSN 2278-5221

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Abstract

Iron plays an essential role in the proliferation of aggressive tumors therefore it represents an ideal target for cancer therapy. Cell free supernatants from a siderophore producing actinobacterium previously isolated from Thailand were tested against six human cancer cell lines including malignant melanoma A 375 (ATCC no.: CRL-1619), colorectal adenocarcinoma SW620 (ATCC
no.: CCL-227), gastric carcinoma Katob III (ATCC no.: HTB-103), liver hepatoblastoma HepG2 (ATCC no.: HB-8065), breast carcinoma BT474 (ATCC no.: HTB-20) and Acute T cell leukemia Jurkat (ATCC no.: CRL-2063). Following treatment of cells with the bacterial culture supernatant the cell viability of A375 cells was dramatically decreased with cell survival of less than 34 % within
48 h. The rest of the cell lines were largely unaffected. Therefore it is suggested that the actinobacterium produced a cytotoxic compound responsible for the cell death by inducing apoptotic activity. We further speculate that this compound was desferioxamine E as the bacterium is known to produce this compound under the culture conditions used.

Item Type: Article
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
R Medicine > RS Pharmacy and materia medica
Divisions: Pharmacy & Biomolecular Sciences
Publisher: IJPMBS
Date Deposited: 15 Sep 2016 09:06
Last Modified: 09 Sep 2017 03:38
DOI or Identification number: ijpmbs_5159a4b1333fe
URI: http://researchonline.ljmu.ac.uk/id/eprint/4147

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