Pujol-Gimenez, J and de Heredia, FP and Angel Idoate, M and Airley, R and Pilar Lostao, M and Evans, AR (2015) Could GLUT12 be a Potential Therapeutic Target in Cancer Treatment? A Preliminary Report. Journal of Cancer, 6 (2). pp. 139-143. ISSN 1837-9664
Glut-12 paper.pdf - Published Version
Background: Recent studies proposed GLUT12 to be a major glucose transporter involved in the glycolytic metabolism of cancer cells.
Methods: GLUT12 expression was determined by immunohistochemistry in a selection of cancer
cell lines and a tumour spheroid model.
Results: GLUT12 expression was high in A549 and RH-36; low in HT29; and absent in NB-EB cancer cell lines. GLUT12 expression was located in the necrotic centre of HT29 spheroids, which
is characterised by anaerobic metabolism.
Conclusion: The data supports the involvement of GLUT12 in the glycolytic metabolism of cancer
cells and therefore, its potential as a novel therapeutic target for cancer treatment.
|Uncontrolled Keywords:||Science & Technology; Life Sciences & Biomedicine; Oncology; GLUT12; Cancer cell lines; Spheroid; Immunohistochemistry; Glycolytic metabolism; FACILITATIVE GLUCOSE TRANSPORTERS; HUMAN PLACENTA; TUMOR HYPOXIA; EXPRESSION; P53; LOCALIZATION; TISSUES; AGENTS; CELLS|
|Subjects:||R Medicine > RS Pharmacy and materia medica|
|Divisions:||Pharmacy & Biomolecular Sciences|
|Publisher:||Ivyspring International Publisher|
|Date Deposited:||21 May 2015 10:28|
|Last Modified:||21 May 2015 10:55|
|DOI or Identification number:||10.7150/jca.10429|
Available Versions of this Item
Could GLUT12 be a Potential Therapeutic Target in Cancer Treatment? A Preliminary Report. (deposited 30 Jan 2015 11:02)
- Could GLUT12 be a Potential Therapeutic Target in Cancer Treatment? A Preliminary Report. (deposited 21 May 2015 10:28) [Currently Displayed]
Actions (login required)