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D-003 (Saccharum officinarum): The forgotten lipid-lowering agent.

Awad, K and Penson, P and Banach, M (2016) D-003 (Saccharum officinarum): The forgotten lipid-lowering agent. Pharmacological Research, 114. pp. 42-46. ISSN 1096-1186

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Abstract

Reduction of elevated cholesterol levels, particularly low-density lipoprotein cholesterol (LDL-C), is essential in primary and secondary prevention of cardiovascular disease (CVD). Therefore there is still a large need for new effective drugs, which would be able to essentially reduce LDL-C and in the consequence CV residual risk. D-003 is a mixture of high aliphatic primary acids purified from sugarcane (Saccharum officinarum) wax. It showed promising hypocholesterolemic effects in both animal and human studies; it significantly lowers both serum total cholesterol (TC) and LDL-C, and increases high-density lipoprotein cholesterol (HDL-C). In addition, it showed a favorable safety profile. In this review, we evaluated the profile of D-003 as a lipid-lowering agent based on data from available preclinical and clinical studies.

Item Type: Article
Uncontrolled Keywords: 1115 Pharmacology And Pharmaceutical Sciences
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Elsevier
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Date Deposited: 12 Dec 2016 10:32
Last Modified: 09 Sep 2017 23:30
DOI or Identification number: 10.1016/j.phrs.2016.10.008
URI: http://researchonline.ljmu.ac.uk/id/eprint/4676

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