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Passive and post-exercise cold-water immersion augments PGC-1α and VEGF expression in human skeletal muscle.

Joo, CH and Allan, R and Drust, B and Close, GL and Jeong, TS and Bartlett, JD and Mawhinney, C and Louhelainen, J and Morton, JP and Gregson, W (2016) Passive and post-exercise cold-water immersion augments PGC-1α and VEGF expression in human skeletal muscle. European Journal of Applied Physiology. ISSN 1439-6327

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Abstract

PURPOSE: We tested the hypothesis that both post-exercise and passive cold water immersion (CWI) increases PGC-1α and VEGF mRNA expression in human skeletal muscle. METHOD: Study 1 Nine males completed an intermittent running protocol (8 × 3-min bouts at 90 % [Formula: see text], interspersed with 3-min active recovery (1.5-min at 25 % and 1.5-min at 50 % [Formula: see text]) before undergoing CWI (10 min at 8 °C) or seated rest (CONT) in a counterbalanced, randomised manner. Study 2 Ten males underwent an identical CWI protocol under passive conditions. RESULTS: Study 1 PGC-1α mRNA increased in CONT (~3.4-fold; P < 0.001) and CWI (~5.9-fold; P < 0.001) at 3 h post-exercise with a greater increase observed in CWI (P < 0.001). VEGFtotal mRNA increased after CWI only (~2.4-fold) compared with CONT (~1.1-fold) at 3 h post-exercise (P < 0.01). Study 2 Following CWI, PGC-1α mRNA expression was significantly increased ~1.3-fold (P = 0.001) and 1.4-fold (P = 0.0004) at 3 and 6 h, respectively. Similarly, VEGF165 mRNA was significantly increased in CWI ~1.9-fold (P = 0.03) and 2.2-fold (P = 0.009) at 3 and 6 h post-immersion. CONCLUSIONS: Data confirm post-exercise CWI augments the acute exercise-induced expression of PGC-1α mRNA in human skeletal muscle compared to exercise per se. Additionally CWI per se mediates the activation of PGC-1α and VEGF mRNA expression in human skeletal muscle. Cold water may therefore enhance the adaptive response to acute exercise.

Item Type: Article
Uncontrolled Keywords: 1106 Human Movement And Sports Science
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Pharmacy & Biomolecular Sciences
Sport & Exercise Sciences
Publisher: Springer Verlag
Related URLs:
Date Deposited: 02 Nov 2016 13:18
Last Modified: 07 Sep 2017 20:07
DOI or Identification number: 10.1007/s00421-016-3480-1
URI: http://researchonline.ljmu.ac.uk/id/eprint/4728

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