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Effects of wine and grape polyphenols on blood pressure, endothelial function and sympathetic nervous system activity in treated hypertensive subjects

Greyling, A and Bruno, RM and Draijer, R and Mulder, T and Thijssen, DHJ and Taddei, S and Virdis, A and Ghiadoni, L (2016) Effects of wine and grape polyphenols on blood pressure, endothelial function and sympathetic nervous system activity in treated hypertensive subjects. Journal of Functional Foods, 27. pp. 448-460. ISSN 1756-4646

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Abstract

In a randomized double-blind crossover trial, the effect of 8 week supplementation with grape and wine polyphenols on functional and structural vascular parameters and autonomic activity was evaluated in 40 essential hypertensive patients treated with diuretic monotherapy. Ambulatory blood pressure, brachial artery flow mediated dilation (FMD) and pulse-wave velocity (PWV) were measured at baseline and after each 8-week intervention. Forearm resistance artery endothelial function and muscle sympathetic nerve activity (MSNA) response to mental stress and cold-pressor test were measured in two separate sub-groups. No statistically significant differences were found across time or between groups in either blood pressure, FMD, PWV, or resistance artery endothelial function. The MSNA response to the two stressors was non-significantly attenuated after grape-wine polyphenol supplementation. These results do not support the hypothesis that daily consumption of a high dose of grape and wine polyphenols lowers blood pressure or affects vascular function in patients already on antihypertensive medication. © 2016 Elsevier Ltd

Item Type: Article
Uncontrolled Keywords: 1111 Nutrition And Dietetics, 0908 Food Sciences
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions: Sport & Exercise Sciences
Publisher: Elsevier
Date Deposited: 10 Nov 2016 12:12
Last Modified: 14 Oct 2017 00:50
DOI or Identification number: 10.1016/j.jff.2016.10.003
URI: http://researchonline.ljmu.ac.uk/id/eprint/4779

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