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Cytotoxic acridone and indoloquinazoline alkaloids from Zanthoxylum poggei

Wansi, JD and Tadjong Tcho, A and Toze, FAA and Nahar, L and Martin, C and Sarker, SD (2016) Cytotoxic acridone and indoloquinazoline alkaloids from Zanthoxylum poggei. Phytochemistry Letters, 17. pp. 293-298. ISSN 1874-3900

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Abstract

Two new alkaloids, poggeicridone (1) and 2-methoxy-7,8- dehydroruteacarpine (6), together with nine known compounds, were isolated from the dichloromethane (DCM) extract of the bark of Zanthoxylum poggei (Engl.) P. G. Waterman. The structures of all compounds were determined by comprehensive spectroscopic analyses (1D and 2D NMR and EI- and ESI–MS). Compounds 5-9 exhibited strong suppressive effects on the phagocytosis response upon activation with serum opsonized zymosan in the in vitro oxidative burst studies using whole blood. The IC50 values were in the range of 12.0–25.9 μM. These compounds displayed a moderate level of cytotoxic activity against the human Caucasian prostate adenocarcinoma cell line PC-3, with IC50 values of 15.8 and 22.1 μM (the IC50 value of the positive control standard doxorubicin was IC50 0.9 μM). All isolated compounds were also tested against plant pathogenic bacteria, fungi and oomycetes using the paper disk agar diffusion assay, resulting in no significant activities (MICs > 1 mg/mL). © 2016 Phytochemical Society of Europe

Item Type: Article
Uncontrolled Keywords: 0304 Medicinal And Biomolecular Chemistry, 0607 Plant Biology, 1115 Pharmacology And Pharmaceutical Sciences
Subjects: R Medicine > RM Therapeutics. Pharmacology
R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Elsevier
Date Deposited: 14 Nov 2016 10:24
Last Modified: 07 Sep 2017 07:32
DOI or Identification number: 10.1016/j.phytol.2016.08.010
URI: http://researchonline.ljmu.ac.uk/id/eprint/4799

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