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Saleem, I, Smyth, H and Telko, M (2008) Prediction of dry powder inhaler formulation performance from surface energetics and blending dynamics. Drug Development and Industrial Pharmacy, 34 (9). pp. 1002-1010. ISSN 0363-9045
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Imran paper Budesonide DPI.pdf - Accepted Version Download (360kB) | Preview |
Abstract
The Purpose of these studies was to investigate the ability of surface energy measurements and rates of mixing in dry powder inhaler formulations to predict aerosol dispersion performance. Two lactose carrier systems comprising either spray dried or milled particles were developed such that they had identical physical characteristics except for surface morphology and surface energies avoiding confounding variables common in other studies. Surface energy measurements confirmed significant differences between the powder systems. Spray dried lactose had a higher surface entropy (0.20 vs.
0.13 mJ/m2K) and surface enthalpy (103.2 vs. 79.2 mJ/m2) compared to milled lactose. Mixing rates of budesonide or fluorescein were assessed dynamically and significant differences in blending were observed between lactose systems for both drugs. Surface energies of the lactose carriers were inversely proportional to dispersion performance. In addition, the root mean square of blending rates correlated positively with aerosol dispersion performance. Both techniques have potential utility in routine screening dry powder inhaler formulations.
| Item Type: | Article |
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| Additional Information: | This is an Accepted Manuscript of an article published by Taylor & Francis in Drug Development and Industrial Pharmacy on 20/10/2008 available online: http://www.tandfonline.com/10.1080/03639040802154905 |
| Uncontrolled Keywords: | 1115 Pharmacology And Pharmaceutical Sciences |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Pharmacy & Biomolecular Sciences |
| Publisher: | Taylor & Francis |
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| Date Deposited: | 01 Dec 2016 11:11 |
| Last Modified: | 04 Sep 2021 12:12 |
| DOI or ID number: | 10.1080/03639040802154905 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/4960 |
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