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Heterochromatin and the molecular mechanisms of 'parent-of-origin' effects in animals.

Singh, PB (2016) Heterochromatin and the molecular mechanisms of 'parent-of-origin' effects in animals. Journal of Biosciences, 41 (4). pp. 759-786. ISSN 0250-5991

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Abstract

Twenty five years ago it was proposed that conserved components of constitutive heterochromatin assemble heterochromatinlike complexes in euchromatin and this could provide a general mechanism for regulating heritable (cell-to-cell) changes in gene expressibility. As a special case, differences in the assembly of heterochromatin-like complexes on homologous chromosomes might also regulate the parent-of-origin-dependent gene expression observed in placental mammals. Here, the progress made in the intervening period with emphasis on the role of heterochromatin and heterochromatin-like complexes in parent-of-origin effects in animals is reviewed.

Item Type: Article
Uncontrolled Keywords: 06 Biological Sciences
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Natural Sciences and Psychology
Publisher: Indian Academy of Sciences
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Date Deposited: 13 Jan 2017 10:17
Last Modified: 07 Sep 2017 04:21
DOI or Identification number: 10.1007/s12038-016-9650-9
URI: http://researchonline.ljmu.ac.uk/id/eprint/5257

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