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Drug interactions with lipid membranes.

Seddon, AM and Casey, DR and Law, RV and Gee, A and Templer, RH and Ces, O (2009) Drug interactions with lipid membranes. Chemical Society Reviews, 38 (9). pp. 2497-2812. ISSN 0306-0012

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Abstract

The field of drug-membrane interactions is one that spans a wide range of scientific disciplines, from synthetic chemistry, through biophysics to pharmacology. Cell membranes are complex dynamic systems whose structures can be affected by drug molecules and in turn can affect the pharmacological properties of the drugs being administered. In this tutorial review we aim to provide a guide for those new to the area of drug-membrane interactions and present an introduction to areas of this topic which need to be considered. We address the lipid composition and structure of the cell membrane and comment on the physical forces present in the membrane which may impact on drug interactions. We outline methods by which drugs may cross or bind to this membrane, including the well understood passive and active transport pathways. We present a range of techniques which may be used to study the interactions of drugs with membranes both in vitro and in vivo and discuss the advantages and disadvantages of these techniques and highlight new methods being developed to further this field.

Item Type: Article
Uncontrolled Keywords: 03 Chemical Sciences
Subjects: Q Science > QD Chemistry
Divisions: Built Environment
Publisher: Royal Society of Chemistry
Related URLs:
Date Deposited: 04 Mar 2015 15:53
Last Modified: 04 Mar 2015 15:53
DOI or Identification number: 10.1039/b813853m
URI: http://researchonline.ljmu.ac.uk/id/eprint/540

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