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Acute impact of conventional and eccentric cycling on platelet and vascular function in patients with chronic heart failure.

Haynes, A and Linden, MD and Chasland, LC and Nosaka, K and Maiorana, AJ and Dawson, EA and Dembo, L and Naylor, LH and Green, DJ (2017) Acute impact of conventional and eccentric cycling on platelet and vascular function in patients with chronic heart failure. Journal of Applied Physiology (1985). ISSN 8750-7587

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Abstract

Evidence-based guidelines recommend exercise therapy for patients with chronic heart failure (CHF). Such patients have increased atherothrombotic risk. Exercise can transiently increase platelet activation and reactivity and decrease vascular function in healthy participants, although data in CHF is scant. Eccentric (ECC) cycling is a novel exercise modality which may be particularly suited to patients with CHF, but the acute impacts of ECC on platelet and vascular function are currently unknown. Our null hypothesis was that ECC and concentric (CON) cycling, performed at matched external workloads, would not induce changes in platelet or vascular function in patients with CHF. Eleven patients with heart failure with reduced ejection fraction (HFrEF) took part in discrete bouts of ECC and CON cycling. Before and immediately after exercise, vascular function was assessed by measuring diameter and flow mediated dilation (FMD) of the brachial artery. Platelet function was measured by the flow cytometric determination of glycoprotein IIb/IIIa activation and granule exocytosis in the presence and absence of platelet agonists. ECC increased baseline artery diameter (pre: 4.0±0.8mm vs post: 4.2±0.7mm, P=0.04) and decreased FMD%. When changes in baseline artery diameter were accounted for the decrease in FMD post-ECC was no longer significant. No changes were apparent after CON. Neither ECC nor CON resulted in changes to any platelet function measures (all P>0.05). These results suggest both ECC and CON cycling at a moderate intensity and short duration can be performed by patients with HFrEF, without detrimental impacts on vascular or platelet function.

Item Type: Article
Uncontrolled Keywords: 06 Biological Sciences, 11 Medical And Health Sciences
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Amercian Physiological Society
Related URLs:
Date Deposited: 30 Mar 2017 09:34
Last Modified: 13 Sep 2017 10:28
DOI or Identification number: 10.1152/japplphysiol.01057.2016
URI: http://researchonline.ljmu.ac.uk/id/eprint/6140

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