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Optimizing the primary particle size distributions of pressurized metered dose inhalers by using inkjet spray drying for targeting desired regions of the lungs

Seton, L and Ehtezazi, T and DAVIES, MJ and Seton, L and MORGAN, NM and ROSS, S and MARTIN, GD and HUTCHINGS, IM (2015) Optimizing the primary particle size distributions of pressurized metered dose inhalers by using inkjet spray drying for targeting desired regions of the lungs. Drug Development and Industrial Pharmacy, 41 (2). pp. 279-291. ISSN 0363-9045

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Abstract

Conventional suspension pressurized metered dose inhalers (pMDIs) suffer not only from delivering small amounts of a drug to the lungs, but also the inhaled dose scatters all over the lung regions. This results in much less of the desired dose being delivered to regions of the lungs. This study aimed to improve the aerosol performance of suspension pMDIs by producing primary particles with narrow size distributions. Inkjet spray drying was used to produce respirable particles of salbutamol sulfate. The Next Generation Impactor (NGI) was used to determine the aerosol particle size distribution and fine particle fraction (FPF). Furthermore, oropharyngeal models were used with the NGI to compare the aerosol performances of a pMDI with monodisperse primary particles and a conventional pMDI. Monodisperse primary particles in pMDIs showed significantly narrower aerosol particle size distributions than pMDIs containing polydisperse primary particles. Monodisperse pMDIs showed aerosol deposition on a single stage of the NGI as high as 41.75 ± 5.76%, while this was 29.37 ± 6.79% for a polydisperse pMDI. Narrow size distribution was crucial to achieve a high FPF (49.31 ± 8.16%) for primary particles greater than 2 µm. Only small polydisperse primary particles with sizes such as 0.65 ± 0.28 µm achieved a high FPF with (68.94 ± 6.22%) or without (53.95 ± 4.59%) a spacer. Oropharyngeal models also indicated a narrower aerosol particle size distribution for a pMDI containing monodisperse primary particles compared to a conventional pMDI. It is concluded that, pMDIs formulated with monodisperse primary particles show higher FPFs that may target desired regions of the lungs more effectively than polydisperse pMDIs. Read More: http://informahealthcare.com/doi/abs/10.3109/03639045.2013.858741

Item Type: Article
Additional Information: This is an Accepted Manuscript of an article published by Taylor & Francis in Drug Development and Industrial Pharmacy on 19th November 2013, available online: http://www.tandfonline.com/10.3109/03639045.2013.858741
Subjects: R Medicine > RS Pharmacy and materia medica
T Technology > TA Engineering (General). Civil engineering (General)
T Technology > TP Chemical technology
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Taylor & Francis
Date Deposited: 09 Jun 2017 10:33
Last Modified: 11 Sep 2017 07:28
DOI or Identification number: 10.3109/03639045.2013.858741
URI: http://researchonline.ljmu.ac.uk/id/eprint/625

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